Virus threatens life health seriously. The accurate early diagnosis of the virus is vital for
clinical control and treatment of virus infection. Aptamers are small single-stranded …

For over 100 years, vaccines have been one of the most effective medical interventions for
reducing infectious disease, and are estimated to save millions of lives globally each year …

The major barrier to research and development of effective interventions for human
noroviruses (HuNoVs) has been the lack of a robust and reproducible in vitro cultivation …

Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …

Virus-like particles (VLPs) are multiprotein structures that mimic the organization and
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …

Noroviruses are now recognized as the leading cause of epidemics of gastroenteritis and an
important cause of sporadic gastroenteritis among both children and adults. In the United …

Background Early in the spring of 1993 there was a widespread outbreak of acute watery
diarrhea among the residents of Milwaukee. Methods We investigated the two Milwaukee …

Background Noroviruses cause epidemic and sporadic acute gastroenteritis. No vaccine is
available to prevent norovirus illness or infection. Methods We conducted a randomized …

Norovirus (NoV) is an enteric non-enveloped virus which is the leading cause of
gastroenteritis across all age groups. It is responsible for around 200,000 deaths annually …

Gastroenteritis, both epidemic and sporadic, is a common cause of morbidity and mortality
among persons of all ages, accounting for over 1.8 million deaths in children under 5 years …