Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide
Angiotensin II (ANG II) is a pleiotropic vasoactive peptide that binds to two distinct receptors:
the ANG II type 1 (AT1) and type 2 (AT2) receptors. Activation of the renin-angiotensin …
the ANG II type 1 (AT1) and type 2 (AT2) receptors. Activation of the renin-angiotensin …
Angiotensin II type 2 receptor: a target for protection against hypertension, metabolic dysfunction, and organ remodeling
The renin-angiotensin system is of vital significance not only in the maintenance of blood
pressure but also because of its role in the pathophysiology of different organ systems in the …
pressure but also because of its role in the pathophysiology of different organ systems in the …
Possible involvement of the adipose tissue renin‐angiotensin system in the pathophysiology of obesity and obesity‐related disorders
GH Goossens, EE Blaak, MA Van Baak - Obesity Reviews, 2003 - Wiley Online Library
Summary Angiotensin II (Ang II), acting on the AT1 and AT2 receptors in mammalian cells, is
the vasoactive component of the renin‐angiotensin system (RAS). Several components of …
the vasoactive component of the renin‐angiotensin system (RAS). Several components of …
[HTML][HTML] Angiotensin AT2 receptors: cardiovascular hope or hype?
RE Widdop, ES Jones, RE Hannan… - British journal of …, 2003 - ncbi.nlm.nih.gov
It is widely accepted that the angiotensin II type 1 receptor (AT1R) accounts for the majority
of cardiovascular effects evoked by angiotensin II (Ang II), such as contraction/pressor …
of cardiovascular effects evoked by angiotensin II (Ang II), such as contraction/pressor …
Angiotensin-(1–7) acts as a vasodepressor agent via angiotensin II type 2 receptors in conscious rats
Given that angiotensin-(1–7)(Ang-[1–7]) has been frequently reported to exert direct in vitro
vascular effects but less often in vivo, we investigated whether a vasodepressor effect of Ang …
vascular effects but less often in vivo, we investigated whether a vasodepressor effect of Ang …
AT2 receptor activities and pathophysiological implications
LC Matavelli, HM Siragy - Journal of cardiovascular pharmacology, 2015 - journals.lww.com
Although angiotensin II subtype-2 receptor (AT2R) was discovered over 2 decades ago, its
contribution to physiology and pathophysiology is not fully elucidated. Current knowledge …
contribution to physiology and pathophysiology is not fully elucidated. Current knowledge …
[HTML][HTML] The non-classical renin-angiotensin system and renal function
MC Chappell - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
The renin-angiotensin-system (RAS) constitutes one of the most important hormonal
systems in the physiological regulation of blood pressure through renal and non-renal …
systems in the physiological regulation of blood pressure through renal and non-renal …
Enhanced angiotensin II type 2 receptor mechanisms mediate decreases in arterial pressure attributable to chronic low-dose angiotensin II in female rats
AK Sampson, KM Moritz, ES Jones, RL Flower… - …, 2008 - Am Heart Assoc
The renin-angiotensin system is a far more complex enzymatic cascade than realized
previously. Mounting evidence suggests sex-specific differences in the regulation of the …
previously. Mounting evidence suggests sex-specific differences in the regulation of the …
Stimulation of angiotensin AT2 receptors by the non‐peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats
S Bosnyak, IK Welungoda, A Hallberg… - British journal of …, 2010 - Wiley Online Library
Background and purpose: Angiotensin type 2 receptor (AT2 receptor) stimulation evokes
vasodilator effects in vitro and in vivo that oppose the vasoconstrictor effects of angiotensin …
vasodilator effects in vitro and in vivo that oppose the vasoconstrictor effects of angiotensin …
Physiological and Pathophysiological Functions of the AT2 Subtype Receptor of Angiotensin II: From Large Arteries to the Microcirculation
Angiotensin II exerts a potent role in the control of hemodynamic and renal homeostasis.
Angiotensin II is also a local and biologically active mediator involved in both endothelial …
Angiotensin II is also a local and biologically active mediator involved in both endothelial …