Effects of Angiotensin Metabolites in the Coronary Vascular Bed of the Spontaneously Hypertensive Rat: Loss of Angiotensin II Type 2 Receptor–Mediated …
E Moltzer, AVA Verkuil, R van Veghel, AHJ Danser… - …, 2010 - Am Heart Assoc
Because angiotensin (Ang) metabolites mediate functions independent of Ang II, we
investigated their effects on coronary flow in spontaneously hypertensive rats (SHRs) …
investigated their effects on coronary flow in spontaneously hypertensive rats (SHRs) …
A Single β-Amino Acid Substitution to Angiotensin II Confers AT2 Receptor Selectivity and Vascular Function
ES Jones, MP Del Borgo, JF Kirsch, D Clayton… - …, 2011 - Am Heart Assoc
Novel AT2R ligands were designed by substituting individual β-amino acid in the sequence
of the native ligand angiotensin II (Ang II). Relative ATR selectivity and functional vascular …
of the native ligand angiotensin II (Ang II). Relative ATR selectivity and functional vascular …
β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious …
We have previously shown that individual β-amino acid substitution in angiotensin (Ang) II
reduced Ang II type 1 receptor (AT1R) but not Ang II type 2 receptor (AT2R)-binding and that …
reduced Ang II type 1 receptor (AT1R) but not Ang II type 2 receptor (AT2R)-binding and that …
Stimulation of Cyclic GMP Production via AT2 and B2 Receptors in the Pressure-Overloaded Aorta After Banding
H Hiyoshi, K Yayama, M Takano, H Okamoto - Hypertension, 2004 - Am Heart Assoc
Abdominal aortic banding induces upregulation of the angiotensin II (Ang II) type-2 (AT2)
receptor, thereby decreasing the contractile response to Ang II in the thoracic aorta of the rat …
receptor, thereby decreasing the contractile response to Ang II in the thoracic aorta of the rat …
Angiotensin receptor blockers: how important is selectivity?
HM Siragy - American journal of hypertension, 2002 - academic.oup.com
During the last decade, angiotensin-receptor blockers have established themselves as
effective antihypertensive agents with impressive safety profile and placebo-like tolerability …
effective antihypertensive agents with impressive safety profile and placebo-like tolerability …
Angiotensin type 2 receptors: potential importance in the regulation of blood pressure
The angiotensin type 2 receptor is one of two major angiotensin II receptors that has been
identified, cloned and sequenced. The other major receptor, the angiotensin type 1 receptor …
identified, cloned and sequenced. The other major receptor, the angiotensin type 1 receptor …
Renal angiotensin II AT2 receptors promote natriuresis in streptozotocin-induced diabetic rats
AC Hakam, AH Siddiqui… - American Journal of …, 2006 - journals.physiology.org
Angiotensin II AT2 receptors have been implicated to play a role in the regulation of
renal/cardiovascular functions under pathological conditions. The present study is designed …
renal/cardiovascular functions under pathological conditions. The present study is designed …
Impact of the AT2 Receptor Agonist C21 on Blood Pressure and Beyond
It is now widely accepted that the angiotensin AT 2 receptor (AT 2 R) plays an important
protective role during pathophysiologic conditions, acting as a repair system. The …
protective role during pathophysiologic conditions, acting as a repair system. The …
Angiotensin II Type-2 receptors modulate inflammation through signal transducer and activator of transcription proteins 3 phosphorylation and TNFα production
Angiotensin subtype-1 receptor (AT1R) influences inflammatory processes through
enhancing signal transducer and activator of transcription proteins 3 (STAT3) signal …
enhancing signal transducer and activator of transcription proteins 3 (STAT3) signal …
[HTML][HTML] Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats
Angiotensin (1-7)(Ang (1-7)) causes vasodilator effects in Wistar-Kyoto (WKY) rats and
spontaneously hypertensive rats (SHRs) via angiotensin type 2 receptors (AT 2 R) …
spontaneously hypertensive rats (SHRs) via angiotensin type 2 receptors (AT 2 R) …