Guidelines Management of severe peri-operative bleeding: Guidelines from the European
Society of Anaesthesiology and Intensive Care

Objective The present meta-analysis was conducted to evaluate the efficacy and safety of
the application of tranexamic acid (TXA) in patients undergoing high tibial osteotomy (HTO) …

Tranexamic acid (TXA) is a commonly used antifibrinolytic agent for perioperative blood
conservation in several surgical specialties. Although historically administered …

Purpose To assess the efficacy and safety of multiple-dose intravenous tranexamic acid (IV-
TXA) on blood loss following total knee arthroplasty (TKA). Methods One hundred fifty nine …

This study aimed to evaluate the efficacy of perioperative intravenous TXA in reducing blood
loss in pelvic and acetabular fracture patients managed surgically. The study included 306 …

Background This is a randomized controlled trial research to assess the hemostatic efficacy
of gelatin sponge, collagen sponge, and topical use of tranexamic acid (TXA) on …

Purpose The objective of this study was to evaluate potential cytotoxicity of TXA on articular
cartilage by assessing chondrocyte viability of osteochondral explants after exposure to …

Aims The aims of this study were to compare the efficacy and safety of intra-articular and
intravenous (IV) tranexamic acid (TXA) in controlling perioperative blood loss in total knee …

Background As an antifibrinolytic agent, tranexamic acid (TXA) is increasingly used in total
knee arthroplasty (TKA) to reduce blood loss. The administration of intravenous and intra …

Blood loss management is critical to positive outcomes in patients undergoing total knee
arthroplasty (TKA). Transfusions are associated with an increased risk of major and minor …