Cancer-associated fibroblasts in the single-cell era
Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …
[HTML][HTML] Epithelial-mesenchymal transition (EMT): the type-2 EMT in wound healing, tissue regeneration and organ fibrosis
GD Marconi, L Fonticoli, TS Rajan, SD Pierdomenico… - Cells, 2021 - mdpi.com
The epithelial–mesenchymal transition (EMT) is an essential event during cell development,
in which epithelial cells acquire mesenchymal fibroblast-like features including reduced …
in which epithelial cells acquire mesenchymal fibroblast-like features including reduced …
[HTML][HTML] Mechanical and physical regulation of fibroblast–myofibroblast transition: from cellular mechanoresponse to tissue pathology
M D'Urso, NA Kurniawan - Frontiers in bioengineering and …, 2020 - frontiersin.org
Fibroblasts are cells present throughout the human body that are primarily responsible for
the production and maintenance of the extracellular matrix (ECM) within the tissues. They …
the production and maintenance of the extracellular matrix (ECM) within the tissues. They …
NOX4 inhibition potentiates immunotherapy by overcoming cancer-associated fibroblast-mediated CD8 T-cell exclusion from tumors
K Ford, CJ Hanley, M Mellone, C Szyndralewiez… - Cancer research, 2020 - AACR
Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy
is key to developing new treatment strategies. Cancer-associated fibroblasts (CAF) have …
is key to developing new treatment strategies. Cancer-associated fibroblasts (CAF) have …
[HTML][HTML] The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling
Cardiac myofibroblasts play an important role in myocardial remodeling. Although α-smooth
muscle actin (α-SMA) expression is the hallmark of mature myofibroblasts, its role in …
muscle actin (α-SMA) expression is the hallmark of mature myofibroblasts, its role in …
[HTML][HTML] Resolution of organ fibrosis
Fibrosis is the excessive accumulation of extracellular matrix that often occurs as a wound
healing response to repeated or chronic tissue injury, and may lead to the disruption of …
healing response to repeated or chronic tissue injury, and may lead to the disruption of …
Skeletal muscle fibrosis: an overview
MAA Mahdy - Cell and tissue research, 2019 - Springer
Extracellular matrix (ECM) is an essential component of skeletal muscle. It provides a
framework structure that holds myofibers and blood capillaries and nerves supplying the …
framework structure that holds myofibers and blood capillaries and nerves supplying the …
Skin changes during ageing
F Bonté, D Girard, JC Archambault… - Biochemistry and cell …, 2019 - Springer
The skin provides the primary protection for the body against external injuries and is
essential in the maintenance of general homeostasis. During ageing, resident cells become …
essential in the maintenance of general homeostasis. During ageing, resident cells become …
Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: the one airway concept revisited
Allergic rhinitis (AR), chronic rhinosinusitis (CRS) and asthma often co‐exist. The one airway
model proposes that disease mechanisms occurring in the upper airway may mirror lower …
model proposes that disease mechanisms occurring in the upper airway may mirror lower …
[HTML][HTML] Muscle injuries and strategies for improving their repair
T Laumonier, J Menetrey - Journal of experimental orthopaedics, 2016 - Springer
Satellite cells are tissue resident muscle stem cells required for postnatal skeletal muscle
growth and repair through replacement of damaged myofibers. Muscle regeneration is …
growth and repair through replacement of damaged myofibers. Muscle regeneration is …