Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder
affecting motor neurons (MNs). Evidences indicate that ALS is a non-cell autonomous …

Macrophages dictate both initiation and resolution of inflammation. During acute
inflammation classically activated macrophages (M1) predominate, and during the …

The constant dialogue between the plant world and the animal world (including man among
them) has been known since the time of Adam and Eve, where an apple was the origin of …

While moderate acute exercise has been associated with strong anti-inflammatory
mechanisms, strenuous exercise has been linked to deleterious inflammatory perturbations …

Activation of microglia is a common denominator and a pathophysiological hallmark of the
central nervous system (CNS) disorders. Damage or CNS disorders can trigger inflammatory …

Many endocrine diseases, including type 1 diabetes mellitus, Graves disease, Addison
disease and Hashimoto disease, originate as an autoimmune reaction that affects disease …

Drug abuse is a major global health and economic problem. However, there are no
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …

Background Despite diverging levels of amyloid-β (Aβ) and TAU pathology, different mouse
models, as well as sporadic AD patients show predictable patterns of episodic memory loss …

MicroRNA‐378a (miR‐378a, previously known as miR‐378) is one of the small noncoding
RNA molecules able to regulate gene expression at posttranscriptional level. Its two mature …

Macrophage polarization between the M2 (repair, protumorigenic) and M1 (inflammatory)
phenotypes is seen as a continuum of states. The detailed transcriptional events and signals …