BACKGROUND: Death and anoxic brain injury from unrecognized postoperative respiratory
depression (PORD) is a serious concern for patient safety. The American Patient Safety …

Patient monitoring on low acuity general hospital wards is currently based largely on
intermittent observations and measurements of simple variables, such as blood pressure …

BACKGROUND: Opioid-related adverse events are a serious problem in hospitalized
patients. Little is known about patients who are likely to experience opioid-induced …

Highlights•Biased MOR ligands discovered using empirical, rational and natural product
approaches.•Biased MOR ligands produce analgesia with fewer side effects in mice and …

Methods We performed a narrative review of the literature on Scopus, PubMed and
Cochrane databases. The research string comprised various combinations of “artificial …

Enhanced recovery programmes (ERPs) are increasingly used to improve post-surgical
recovery. However, compliance to various components of ERPs—a key determinant of …

Respiratory depression is common in patients recovering from surgery and anaesthesia.
Failure to recognise and lack of timely institution of intervention can lead to catastrophic …

Background. The efficacy and adverse reactions of remimazolam besylate (RB) in
combination with alfentanil in patients with painless gastroscopy remain unclear. Objective …

Predicting episodes or severity of cardiorespiratory decompensation has proved to be
challenging in patients with stable surgical or medical conditions, recovering on the general …

BACKGROUND: Early detection and prevention of extubation failure offers the potential to
improve patient outcome. The primary aim of this study was to compare the predictive ability …