The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

The renin-angiotensin system (RAS) is undisputedly one of the most prominent endocrine
(tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive …

Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

For many years, modulators of the renin angiotensin system (RAS) have been trusted by
clinicians for the control of essential hypertension. It was recently demonstrated that these …

This review is an updated and expanded version of the three prior reviews that were
published in this journal in 1997, 2003, and 2007. In the case of all approved therapeutic …

The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the regulation of
blood pressure and body fluid homeostasis and is a mainstay for the treatment of …

This review is an updated and expanded version of two prior reviews that were published in
this journal in 1997 and 2003. In the case of all approved agents the time frame has been …

The angiotensin II receptors AT1R and AT2R serve as key components of the renin–
angiotensin–aldosterone system. AT1R has a central role in the regulation of blood …

For cancers to develop, sustain and spread, the appropriation of key homeostatic
physiological systems that influence cell growth, migration and death, as well as …