MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension

AM Santamans, B Cicuéndez, A Mora… - Science …, 2024 - science.org
Pulmonary hypertension (PH) can affect both pulmonary arterial tree and cardiac function,
often leading to right heart failure and death. Despite the urgency, the lack of understanding …

[HTML][HTML] Endotyping COPD: hypoxia-inducible factor-2 as a molecular “switch” between the vascular and airway phenotypes?

O Myronenko, V Foris, S Crnkovic… - European …, 2023 - Eur Respiratory Soc
COPD is a heterogeneous disease with multiple clinical phenotypes. COPD endotypes can
be determined by different expressions of hypoxia-inducible factors (HIFs), which, in …

The efficacy and safety of high-flow nasal cannula therapy in patients with COPD and type II respiratory failure: a meta-analysis and systematic review

Z Xu, L Zhu, J Zhan, L Liu - European journal of medical research, 2021 - Springer
Background High-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) have been
used for the treatment of COPD and respiratory failure in clinical settings. We aimed to …

Actualización de la Guía Española de la EPOC (GesEPOC): comorbilidades, automanejo y cuidados paliativos

JL Lopez-Campos, P Almagro, JT Gómez… - Archivos de …, 2022 - Elsevier
Los modelos de atención sanitaria actuales descritos en GesEPOC indican la mejor manera
de hacer un diagnóstico correcto, la categorización de los pacientes, la adecuada selección …

[Translated article] Spanish COPD Guideline (GesEPOC) Update: Comorbidities, Self-Management and Palliative Care

JL Lopez-Campos, P Almagro, JT Gómez… - Archivos de …, 2022 - Elsevier
The current health care models described in GesEPOC indicate the best way to make a
correct diagnosis, the categorization of patients, the appropriate selection of the therapeutic …

[HTML][HTML] Treatment of pulmonary hypertension associated with COPD: a systematic review

R Arif, A Pandey, Y Zhao, K Arsenault-Mehta… - ERJ Open …, 2022 - Eur Respiratory Soc
Chronic obstructive pulmonary disease-associated pulmonary hypertension (COPD-PH) is
an increasingly recognised condition which contributes to worsening dyspnoea and poor …

The challenge to decide between pulmonary hypertension due to chronic lung disease and PAH with chronic lung disease

H Olschewski - Diagnostics, 2021 - mdpi.com
Chronic lung diseases are strongly associated with pulmonary hypertension (PH), and even
mildly elevated pulmonary arterial pressures are associated with increased mortality …

The effect of long-term doxycycline treatment in a mouse model of cigarette smoke-induced emphysema and pulmonary hypertension

S Hadzic, CY Wu, M Gredic… - … of Physiology-Lung …, 2021 - journals.physiology.org
Chronic obstructive pulmonary disease (COPD) is a major cause of death and a still
incurable disease, comprising emphysema and chronic bronchitis. In addition to airflow …

CEACAM6 as a Novel Therapeutic Target to Boost HO-1—mediated Antioxidant Defense in COPD

CY Wu, A Cilic, O Pak, RC Dartsch… - American Journal of …, 2023 - atsjournals.org
Rationale: Tobacco smoking and air pollution are primary causes of chronic obstructive
pulmonary disease (COPD). However, only a minority of smokers develop COPD. The …

Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary …

H Qi, H Liu, SS Pullamsetti, S Günther, C Kuenne… - Circulation, 2021 - Am Heart Assoc
Background: The pathogenesis of life-threatening cardiopulmonary diseases such as
pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD) originates …