Immunotherapies in chronic pain through modulation of neuroimmune interactions
It is generally believed that immune activation can elicit pain through production of
inflammatory mediators that can activate nociceptive sensory neurons. Emerging evidence …
inflammatory mediators that can activate nociceptive sensory neurons. Emerging evidence …
Glia-neurotrophic factor relationships: possible role in pathobiology of neuroinflammation-related brain disorders
E Palasz, A Wilkaniec, L Stanaszek… - International Journal of …, 2023 - mdpi.com
Neurotrophic factors (NTFs) play an important role in maintaining homeostasis of the central
nervous system (CNS) by regulating the survival, differentiation, maturation, and …
nervous system (CNS) by regulating the survival, differentiation, maturation, and …
Decreased MFN2 activates the cGAS-STING pathway in diabetic myocardial ischaemia–reperfusion by triggering the release of mitochondrial DNA
Y Xiong, Y Leng, H Tian, X Deng, W Li, W Li… - Cell Communication and …, 2023 - Springer
Background The cause of aggravation of diabetic myocardial damage is yet to be
elucidated; damage to mitochondrial function has been a longstanding focus of research …
elucidated; damage to mitochondrial function has been a longstanding focus of research …
Regulation of microglia related neuroinflammation contributes to the protective effect of Gelsevirine on ischemic stroke
C Xing, J Lv, Z Zhu, W Cong, H Bian, C Zhang… - Frontiers in …, 2023 - frontiersin.org
Stroke, especially ischemic stroke, is an important cause of neurological morbidity and
mortality worldwide. Growing evidence suggests that the immune system plays an intricate …
mortality worldwide. Growing evidence suggests that the immune system plays an intricate …
[HTML][HTML] Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice
AS Prudente, SH Lee, J Roh, DD Luckemeyer… - Brain, Behavior, and …, 2024 - Elsevier
Microglia, resident immune cells in the central nervous system, play a role in
neuroinflammation and the development of neuropathic pain. We found that the stimulator of …
neuroinflammation and the development of neuropathic pain. We found that the stimulator of …
cGLRs Join Their Cousins of Pattern Recognition Receptor Family to Regulate Immune Homeostasis
V Kumar, JH Stewart IV - International Journal of Molecular Sciences, 2024 - mdpi.com
Pattern recognition receptors (PRRs) recognize danger signals such as PAMPs/MAMPs and
DAMPs to initiate a protective immune response. TLRs, NLRs, CLRs, and RLRs are well …
DAMPs to initiate a protective immune response. TLRs, NLRs, CLRs, and RLRs are well …
Research progress of cGAS-STING signaling pathway in intestinal diseases
J Wang, N Yao, Y Chen, X Li, Z Jiang - International Immunopharmacology, 2024 - Elsevier
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signal has
drawn much consideration due to its sensitivity to DNA in innate immune mechanisms …
drawn much consideration due to its sensitivity to DNA in innate immune mechanisms …
Identification of (−)-Epigallocateshin gallate derivatives promoting innate immune activation via 2′, 3′-cyclic GMP-AMP-stimulator of interferon genes pathway
H Lee, JH Jeong, T Lee, Y Chong, H Choo… - Bioorganic & Medicinal …, 2023 - Elsevier
Epigallocatehin-3-gallate (EGCG) is a catechin derived from green tea, which has been
widely studied for its anti-oxidant and anti-tumor properties. Although EGCG plays important …
widely studied for its anti-oxidant and anti-tumor properties. Although EGCG plays important …
Neuronal aging is associated with declined autophagy caused by reduced functionality of cGAS-STING signaling
S Passarella, K Brandes, E Dankert, P Cavalli… - bioRxiv, 2023 - biorxiv.org
The lifelong maintenance of cognitive abilities in an increasingly aging human society is one
of the major challenges of future research and medical services. For this, a better …
of the major challenges of future research and medical services. For this, a better …