The complex role of tumor-infiltrating macrophages
Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and
immune defense against pathogens, macrophages are being re-discovered as regulators of …
immune defense against pathogens, macrophages are being re-discovered as regulators of …
[HTML][HTML] The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment
M Yang, J Li, P Gu, X Fan - Bioactive materials, 2021 - Elsevier
The tumor development and metastasis are closely related to the structure and function of
the tumor microenvironment (TME). Recently, TME modulation strategies have attracted …
the tumor microenvironment (TME). Recently, TME modulation strategies have attracted …
The apoptosis paradox in cancer
O Morana, W Wood, CD Gregory - International journal of molecular …, 2022 - mdpi.com
Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …
Inflammation and cancer: triggers, mechanisms, and consequences
FR Greten, SI Grivennikov - Immunity, 2019 - cell.com
Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …
Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis
S Qiu, L Xie, C Lu, C Gu, Y Xia, J Lv, Z Xuan… - Journal of Experimental …, 2022 - Springer
Background Liver metastasis (LM) is a major obstacle to the prognosis of gastric cancer
(GC) patients, but the molecular mechanism underlying gastric cancer liver metastasis (GC …
(GC) patients, but the molecular mechanism underlying gastric cancer liver metastasis (GC …
Tumor-associated macrophages: recent insights and therapies
J Zhou, Z Tang, S Gao, C Li, Y Feng, X Zhou - Frontiers in oncology, 2020 - frontiersin.org
Macrophages, which have functions of engulfing and digesting foreign substances, can
clear away harmful matter, including cellular debris and tumor cells. Based on the condition …
clear away harmful matter, including cellular debris and tumor cells. Based on the condition …
Polarization of Tumor-Associated Macrophages by Nanoparticle-Loaded Escherichia coli Combined with Immunogenic Cell Death for Cancer Immunotherapy
B Wei, J Pan, R Yuan, B Shao, Y Wang, X Guo… - Nano Letters, 2021 - ACS Publications
The tumor immunosuppressive microenvironment greatly limits the efficacy of
immunotherapy. Tumor-associated macrophages (TAMs) are the most abundant …
immunotherapy. Tumor-associated macrophages (TAMs) are the most abundant …
Macrophage plasticity, polarization, and function in health and disease
A Shapouri‐Moghaddam… - Journal of cellular …, 2018 - Wiley Online Library
Macrophages are heterogeneous and their phenotype and functions are regulated by the
surrounding micro‐environment. Macrophages commonly exist in two distinct subsets: 1) …
surrounding micro‐environment. Macrophages commonly exist in two distinct subsets: 1) …
Dual effect of immune cells within tumour microenvironment: pro-and anti-tumour effects and their triggers
AC Peña-Romero, E Orenes-Piñero - Cancers, 2022 - mdpi.com
Simple Summary The relationship between the immune system and tumours is currently one
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …
Therapy-induced evolution of human lung cancer revealed by single-cell RNA sequencing
Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …