[HTML][HTML] Noncanonical DNA structures are drivers of genome evolution
KD Makova, MH Weissensteiner - Trends in Genetics, 2023 - cell.com
In addition to the canonical right-handed double helix, other DNA structures, termed 'non-B
DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular …
DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular …
[HTML][HTML] Multimeric G-quadruplexes: A review on their biological roles and targeting
In human cells, nucleic acids adopt several non-canonical structures that regulate key
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …
G-quadruplex targeting in the fight against viruses: An update
G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of
key cellular processes, such as transcription and replication. Since their discovery, G4s have …
key cellular processes, such as transcription and replication. Since their discovery, G4s have …
G4-quadruplex-binding proteins: review and insights into selectivity
V Meier-Stephenson - Biophysical reviews, 2022 - Springer
There are over 700,000 putative G4-quadruplexes (G4Qs) in the human genome, found
largely in promoter regions, telomeres, and other regions of high regulation. Growing …
largely in promoter regions, telomeres, and other regions of high regulation. Growing …
Peptides selected by G4-mRNA display-seq enable RNA G-quadruplex recognition and gene regulation
G-quadruplexes (G4s) are noncanonical secondary structures that play critical roles in both
chemistry and biology. Although several approaches have been developed for G4 targeting …
chemistry and biology. Although several approaches have been developed for G4 targeting …
Mechanistic insights into the ligand-induced unfolding of an RNA G-quadruplex
S Haldar, Y Zhang, Y Xia, B Islam, S Liu… - Journal of the …, 2022 - ACS Publications
The cationic porphyrin TMPyP4 is a well-established DNA G-quadruplex (G4) binding ligand
that can stabilize different topologies via multiple binding modes. However, TMPyP4 can …
that can stabilize different topologies via multiple binding modes. However, TMPyP4 can …
[HTML][HTML] Major achievements in the design of quadruplex-interactive small molecules
Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …
acids have great potential as selective drugs or as tools in drug target discovery programs …
Visualization of deep tissue G-quadruplexes with a novel large stokes-shifted red fluorescent benzothiazole derivative
G-quadruplex (G4) is a noncanonical nucleic acid secondary structure that has implications
for various physiological and pathological processes and is thus essential to exploring new …
for various physiological and pathological processes and is thus essential to exploring new …
[HTML][HTML] G-quadruplex resolution: From molecular mechanisms to physiological relevance
K Sato, P Knipscheer - DNA repair, 2023 - Elsevier
Guanine-rich DNA sequences can fold into stable four-stranded structures called G-
quadruplexes or G4s. Research in the past decade demonstrated that G4 structures are …
quadruplexes or G4s. Research in the past decade demonstrated that G4 structures are …
RNA G-quadruplexes and stress: emerging mechanisms and functions
RNA G-quadruplexes (rG4s) are noncanonical secondary structures formed by guanine-rich
sequences that are found in different regions of RNA molecules. These structures have been …
sequences that are found in different regions of RNA molecules. These structures have been …