Cross-species virus transmission and the emergence of new epidemic diseases
CR Parrish, EC Holmes, DM Morens… - Microbiology and …, 2008 - Am Soc Microbiol
Host range is a viral property reflecting natural hosts that are infected either as part of a
principal transmission cycle or, less commonly, as “spillover” infections into alternative hosts …
principal transmission cycle or, less commonly, as “spillover” infections into alternative hosts …
AP-1 signaling pathway promotes pro-IL-1β transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection
ABSTRACT NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading
to cell death called pyroptosis constituting a major antiviral host defense and inflammatory …
to cell death called pyroptosis constituting a major antiviral host defense and inflammatory …
Dynamics of influenza virus infection and pathology
RA Saenz, M Quinlivan, D Elton, S MacRae… - Journal of …, 2010 - Am Soc Microbiol
ABSTRACT A key question in pandemic influenza is the relative roles of innate immunity
and target cell depletion in limiting primary infection and modulating pathology. Here, we …
and target cell depletion in limiting primary infection and modulating pathology. Here, we …
Innate immune evasion strategies of influenza viruses
BG Hale, RA Albrecht, A García-Sastre - Future microbiology, 2010 - Taylor & Francis
Influenza viruses are globally important human respiratory pathogens. These viruses cause
seasonal epidemics and occasional worldwide pandemics, both of which can vary …
seasonal epidemics and occasional worldwide pandemics, both of which can vary …
The role of swine in the generation of novel influenza viruses
W Ma, KM Lager, AL Vincent, BH Janke… - Zoonoses and public …, 2009 - Wiley Online Library
The ecology of influenza A viruses is very complicated involving multiple host species and
viral genes. Avian species have variable susceptibility to influenza A viruses with wild …
viral genes. Avian species have variable susceptibility to influenza A viruses with wild …
[HTML][HTML] Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice
J Zhao, J Zhao, N Van Rooijen, S Perlman - PLoS pathogens, 2009 - journals.plos.org
Severe Acute Respiratory Syndrome caused substantial morbidity and mortality during the
2002–2003 epidemic. Many of the features of the human disease are duplicated in BALB/c …
2002–2003 epidemic. Many of the features of the human disease are duplicated in BALB/c …
Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex
JR Rodriguez-Madoz, A Belicha-Villanueva… - Journal of …, 2010 - Am Soc Microbiol
Dengue virus (DENV) is the most prevalent arthropod-borne human virus, able to infect and
replicate in human dendritic cells (DCs), inducing their activation and the production of …
replicate in human dendritic cells (DCs), inducing their activation and the production of …
Immunomodulatory therapy for severe influenza
I Darwish, S Mubareka, WC Liles - Expert review of anti-infective …, 2011 - Taylor & Francis
Influenza A virus is a significant cause of morbidity and mortality worldwide. Severe
influenza is recognized as a clinical syndrome, characterized by hyperinduction of …
influenza is recognized as a clinical syndrome, characterized by hyperinduction of …
Dengue virus inhibits the production of type I interferon in primary human dendritic cells
JR Rodriguez-Madoz, D Bernal-Rubio… - Journal of …, 2010 - Am Soc Microbiol
Dengue virus (DENV) infects human immune cells in vitro and likely infects dendritic cells
(DCs) in vivo. DENV-2 productive infection induces activation and release of high levels of …
(DCs) in vivo. DENV-2 productive infection induces activation and release of high levels of …