In the United States, 36.5% of women between the ages of 20 and 39 years are obese. This
obesity results in not only metabolic disorders including type II diabetes and cardiovascular …

Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder of premenopausal
women worldwide and is characterized by reproductive, endocrine, and metabolic …

Microplastics (MPs) are an emerging pollutant that is becoming recognized as an
increasingly serious environmental problem. The biological toxicity and resulting health risks …

The ovary is the first organ to age in humans with functional decline evident already in
women in their early 30s. Reproductive aging is characterized by a decrease in oocyte …

Mitochondrial toxicity is an important safety endpoint in drug discovery. Models based solely
on chemical structure for predicting mitochondrial toxicity are currently limited in accuracy …

The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …

Lipids are a potential reservoir of energy for initial embryonic development before activation
of the embryonic genome and are involved in plasma membrane biosynthesis. Excessive …

This is a short review of the basic molecular mechanisms of ovarian aging, written with a
particular focus on the use of this data to improve the diagnostic and therapeutic protocols …

Polycystic ovary syndrome (PCOS) is a complex, but relatively common endocrine disorder
associated with chronic anovulation, hyperandrogenism, and micro-polycystic ovaries. In …

Mitochondria are dynamic organelles that continually adapt their structure through fusion
and fission in response to changes in their bioenergetic environment. Targeted deletion of …