Current insights and emerging trends in early-onset type 2 diabetes

S Misra, C Ke, S Srinivasan, A Goyal… - The Lancet Diabetes & …, 2023 - thelancet.com
Type 2 diabetes diagnosed in childhood or early adulthood is termed early-onset type 2
diabetes. Cases of early-onset type 2 diabetes are increasing rapidly globally, alongside …

Cardiorenal diseases in type 2 diabetes mellitus: clinical trials and real-world practice

LL Lim, E Chow, JCN Chan - Nature Reviews Endocrinology, 2023 - nature.com
Patients with type 2 diabetes mellitus (T2DM) can have multiple comorbidities and
premature mortality due to atherosclerotic cardiovascular disease, hospitalization with heart …

Precision medicine for cardiometabolic disease: a framework for clinical translation

PW Franks, WT Cefalu, J Dennis, JC Florez… - The Lancet Diabetes & …, 2023 - thelancet.com
Cardiometabolic disease is a major threat to global health. Precision medicine has great
potential to help to reduce the burden of this common and complex disease cluster, and to …

Ionically cross-linked alginate-chitosan core-shell hydrogel beads for oral delivery of insulin

VHG Phan, R Mathiyalagan, MT Nguyen… - International Journal of …, 2022 - Elsevier
Here, core-shell hydrogel beads for oral insulin delivery at intestine was reported, which was
a target site for insulin absorption. The core-shell hydrogel beads were prepared using …

Progress in genetics of type 2 diabetes and diabetic complications

N Shojima, T Yamauchi - Journal of Diabetes Investigation, 2023 - Wiley Online Library
Type 2 diabetes results from a complex interaction between genetic and environmental
factors. Precision medicine for type 2 diabetes using genetic data is expected to predict the …

Revolutionary innovations in diabetes research: from biomarkers to genomic medicine

T Addissouky, M Ali… - Iranian journal of …, 2023 - publish.kne-publishing.com
Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia resulting
from inadequate insulin signaling. Current management relies on biomarkers such as …

Safety and efficacy analyses across age and body mass index subgroups in East Asian participants with type 2 diabetes in the phase 3 tirzepatide studies (SURPASS …

A Kiyosue, JP Dunn, X Cui, A Hickey… - Diabetes, Obesity …, 2023 - Wiley Online Library
Aim To assess the safety and efficacy of tirzepatide in people of East Asian descent based
on age and body mass index (BMI). Materials and Methods Data of participants enrolled in …

Dulaglutide protects mice against diabetic sarcopenia‐mediated muscle injury by inhibiting inflammation and regulating the differentiation of Myoblasts

F Deng, W Wu, X Fan, X Zhong, N Wang… - International Journal …, 2023 - Wiley Online Library
Background. Type 2 diabetes mellitus increases the risk of sarcopenia, which is
characterized by decreased muscle mass, strength, and function. However, there are no …

Ethnic differences between Asians and non-Asians in clustering-based phenotype classification of adult-onset diabetes mellitus: a systematic narrative review

JS Varghese, KMV Narayan - Primary care diabetes, 2022 - Elsevier
Several international studies have stratified people with diabetes into phenotypical clusters.
However, there has not been a systematic examination of the variation in these clusters …

Global burden of type 2 diabetes attributable to non-high body mass index from 1990 to 2019

J Wu, Z Feng, J Duan, Y Li, P Deng, J Wang, Y Yang… - BMC Public Health, 2023 - Springer
Background The prevalence of type 2 diabetes mellitus (T2DM) currently was increased in
some countries of the world like China. However, the epidemiological trends of T2DM …