A dominant area of antibody research is the extension of the use of this mighty experimental
and therapeutic tool for the specific detection of molecules for diagnostics, visualization, and …

Anticalin proteins are an emerging class of clinical-stage biopharmaceuticals with high
potential as an alternative to antibodies. Anticalin molecules are generated by combinatorial …

Introduction Anticalin proteins are engineered versions of lipocalins that constitute a novel
class of clinical-stage biopharmaceuticals. The lipocalins exhibit a central β-barrel with eight …

Initially emerging as a highly innovative concept in the late 1990s, the concept of creating
novel binding reagents based on stable protein scaffolds from outside the immunoglobulin …

Members of the vascular endothelial growth factor receptor (VEGFR) family play a central
role in angiogenesis as well as lymphangiogenesis and are crucial for tumor growth and …

We describe the comparative X-ray structural analysis of three Anticalin proteins directed
against the extra-domain B (ED-B) of oncofetal fibronectin (Fn), a validated marker of tumor …

Phage display technology has revolutionized the science of drug discovery by transforming
the generation and manipulation of ligands, such as antibody fragments, enzymes, and …

Mitochondrial outer membrane (MOM) associated proteins are critical players in
mitochondrial transport, dynamics, and quality control. The MOM-anchored GTPase, Miro1 …

The biopharmaceutical industry is becoming increasingly reliant on recombinant proteins as
therapeutic agents. The work presented here details the development of rapid mammalian …

Limitations associated with immunoglobulins have motivated the search for novel binding
scaffolds. Repeat proteins have emerged as one promising class of scaffolds, but often are …