Substantial night-to-night variability in obstructive sleep apnoea (OSA) severity has raised
misdiagnosis and misdirected treatment concerns with the current prevailing single-night …

Obstructive sleep apnoea is a challenging medical problem due to its prevalence, its impact
on quality of life and performance in school and professionally, the implications for risk of …

Abstract Treatment of OSA with CPAP is currently the recommended treatment and has the
greatest evidence of efficacy on AHI, symptoms and comorbidities. Symptomatic patients …

Excessive daytime sleepiness (EDS) is a major symptom of obstructive sleep apnoea (OSA),
defined as the inability to stay awake during the day. Its clinical descriptors remain elusive …

Rationale: The combination of noradrenergic and antimuscarinic agents has recently been
shown to improve upper-airway function and reduce obstructive sleep apnea (OSA) severity …

Background Mechanisms underlying blood pressure changes in obstructive sleep apnoea
(OSA) are incompletely understood. Increased respiratory effort is one of the main features …

Objective To evaluate the efficacy and adverse effects of hypoglossal nerve stimulation in
adolescents with down syndrome and obstructive sleep apnea. Methods A systematic …

Background Potassium (K+) channel inhibition has been identified in animal models as a
potential target to increase pharyngeal dilator muscle activity and to treat OSA. However …

Background Continuation of continuous positive airway pressure (CPAP) therapy after initial
prescription has been shown to reduce all-cause mortality versus therapy termination …

Introduction Clinical presentation of both insomnia and obstructive sleep apnea (COMISA) is
common. Approximately 30% of clinical cohorts with OSA have insomnia symptoms and vice …