The peptide hormone adrenomedullin (ADM) consists of 52 amino acids and plays a pivotal
role in the regulation of many physiological processes, particularly those of the …

Signalling of the calcitonin-like receptor (CLR) is multifaceted, due to its interaction with
receptor activity modifying proteins (RAMPs), and three endogenous peptide agonists …

Background and Purpose The calcitonin (CT) receptor family is complex, comprising two
receptors (the CT receptor [CTR] and the CTR‐like receptor [CLR]), three accessory proteins …

Calcitonin gene-related peptide (CGRP) or adrenomedullin (AM) receptors are heteromers
of the calcitonin receptor-like receptor (CLR), a class BG protein-coupled receptor, and one …

Bladder urothelium and suburothelium/lamina propria (LP) have prominent sensory and
transducer functions with the active participation of afferent neurons and urothelium-derived …

Theoretical models of G protein-coupled receptor (GPCR) concentration-response
relationships often assume an agonist producing a single functional response via a single …

Endogenous satiety hormones provide an attractive target for obesity drugs. Glucagon
causes weight loss by reducing food intake and increasing energy expenditure. To further …

The hormone adrenomedullin has both physiological and pathological roles in biology. As a
potent vasodilator, adrenomedullin is critically important in the regulation of blood pressure …

Supressed levels of intracellular cAMP have been associated with malignancy. Thus,
elevating cAMP through activation of adenylyl cyclase (AC) or by inhibition of …

Adrenomedullin 2/intermedin (AM2/IMD), adrenomedullin (AM), and calcitonin gene-related
peptide (CGRP) have functions in the cardiovascular, lymphatic, and nervous systems by …