Migraine is a common chronic neurovascular disease characterized by headaches.
Calcitonin gene-related peptide (CGRP) signaling in the trigeminovascular system plays a …

The neuropeptide calcitonin gene-related peptide (CGRP) is known to play a central role in
the underlying pathophysiology of migraine. In comparison to the effective triptan class of …

The canonical CGRP receptor is a complex between calcitonin receptor-like receptor (CLR),
a family B G-protein-coupled receptor (GPCR) and receptor activity-modifying protein 1 …

Receptor activity-modifying proteins (RAMPs) are known to modulate the pharmacology and
function of several G protein-coupled receptors (GPCRs), including the parathyroid hormone …

Cluster headache is a disabling neurologic disorder that is characterized by daily, attacks of
very severe, strictly unilateral pain occurring over a period of weeks or months. Recently …

Abstract Receptor Activity Modifying Proteins (RAMPs) serve as accessory proteins that
modulate the signaling activities of G-Protein Coupled Receptors (GPCRs). RAMPs function …

РЕЗЮМЕ Мигрень—одно из наиболее распространенных неврологических
заболеваний, проявляющихся приступами головной боли. Ключевую роль в …

G protein-coupled receptors (GPCRs) are transmembrane proteins that modulate physiology
across diverse tissues in response to extracellular signals. GPCR signalling can differ due to …

Agonist bias at G protein-coupled receptors has attracted considerable interest, although its
relevance for physiologically-produced agonists is not always clear. Here, using primary …

Als Vorläuferzellen von Osteoklasten spielen Makrophagen während der Osteogenese eine
wichtige Rolle. Bei Patienten mit Osteoarthrose (OA) ist der balancierte Prozess aus …