The phases of swallowing are controlled by central pattern-generating circuitry of the brain
stem and peripheral reflexes. The oral, pharyngeal, and esophageal phases of swallowing …

Gastrointestinal (GI) vagal afferents convey sensory signals from the GI tract to the brain.
Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut …

This protocol details methods to identify and record from cutaneous primary afferent axons in
an isolated mammalian skin–saphenous nerve preparation. The method is based on …

The gastrointestinal (GI) tract is a system of organs within multicellular animals which
facilitates the ingestion, digestion, and absorption of food with subsequent defecation of …

Cold thermoreceptors have been described in different territories of the vagus nerve.
Application of cold temperature to these visceral afferents can evoke major protective …

Using a recently developed in vitro preparation of vagal afferent pathways, we examined the
role of TRPV1 and ASIC3 on the mechano-and chemosensitive properties of …

Vagal afferent nerves are essential for optimal neural regulation of visceral organs, but are
not often considered important for their defense. However, there are well-defined subsets of …

TRPM8 and TRPA1 are cold-activated transient receptor potential (TRP) cation channels.
TRPM8 is activated by moderate cooling, while TRPA1 is activated by extreme, noxious cold …

Chronic cough in gastroesophageal reflux disease (GERD) has been attributed to irritation
of the esophagus and/or upper airways by reflux of gastric content. Animal models have …

Swallow is a complex behavior that consists of three coordinated phases: oral, pharyngeal,
and esophageal. Esophageal distension (EDist) has been shown to elicit pharyngeal …