Introduction: Mental health in indigenous communities is a relevant issue for the World
Health Organization (WHO). These communities are supposed to live in a pure, clean and …

Breast cancer is the most frequent cause of cancer death in low-and middle-income
countries, in particular among sub-Saharan African women, where response to available …

Background Warfarin dose variability observed in patients is attributed to variation in genes
involved in the warfarin metabolic pathway. Genetic variation in CYP2C9 and VKORC1 has …

Coumarins such as warfarin are prescribed for prevention and treatment of thromboembolic
disorders. Warfarin remains the most widely prescribed and an anticoagulant of choice in …

Polymorphisms in CYP2C8 and CYP3A5 genes have implications for responses elicited by
the ingestion of some xenobiotics, the metabolism of which are mediated by these enzymes …

Identification of inter-individual variability for drug metabolism through cytochrome P450 2B6
(CYP2B6) enzyme is important for understanding the differences in clinical responses to …

Abstract Background Cytochrome P450 (CYP) enzymes are essential in the metabolism of
most drugs used today. Single nucleotide polymorphism (s) occurring in CYP genes can …

Background Studies on the pharmacogenomic of psychiatric drugs have slowly identified
genetic variations that influence drug metabolism and treatment outcomes, including …

Background African populations are characterised by high genetic diversity, which provides
opportunities for discovering and elucidating novel variants of clinical importance, especially …

Introduction: Warfarin is the most widely prescribed anticoagulant for the prevention and
treatment of thromboembolic diseases. However, warfarin use is complicated by its narrow …