GLP-1 receptor agonists and atherosclerosis protection: the vascular endothelium takes center stage

B Park, E Bakbak, H Teoh… - American Journal …, 2024 - journals.physiology.org
Atherosclerotic cardiovascular disease is a chronic condition that often copresents with type
2 diabetes and obesity. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are incretin …

[HTML][HTML] The cellular and protein arms of coagulation in diabetes: established and potential targets for the reduction of thrombotic risk

NZ Safdar, N Kietsiriroje, RA Ajjan - International Journal of Molecular …, 2023 - mdpi.com
Diabetes is a metabolic condition with a rising global prevalence and is characterised by
abnormally high blood glucose levels. Cardiovascular disease (CVD) accounts for the …

[HTML][HTML] The Role of Cilostazol, a Phosphodiesterase-3 Inhibitor, in the Development of Atherosclerosis and Vascular Biology: A Review with Meta-Analysis

M Sohn, S Lim - International Journal of Molecular Sciences, 2024 - mdpi.com
Atherosclerotic cardiovascular disease (ASCVD) stands as the leading global cause of
mortality. Addressing this vital and pervasive condition requires a multifaceted approach, in …

Trends in cardiovascular disease incidence among 22 million people in the UK over 20 years: population based study

N Conrad, G Molenberghs, G Verbeke, F Zaccardi… - bmj, 2024 - bmj.com
Objective To investigate the incidence of cardiovascular disease (CVD) overall and by age,
sex, and socioeconomic status, and its variation over time, in the UK during 2000-19. Design …

SGLT2 inhibitors: from glucose-lowering to cardiovascular benefits

A Preda, F Montecucco, F Carbone… - Cardiovascular …, 2024 - academic.oup.com
An increasing number of individuals are at high risk of type 2 diabetes (T2D) and its
cardiovascular complications, including heart failure (HF), chronic kidney disease (CKD) …

Potential renoprotective effect of SGLT2 inhibitors against contrast-induced AKI in diabetic STEMI patients undergoing primary PCI

B Kültürsay, C Yılmaz, B Güven… - Polish Heart Journal …, 2024 - journals.viamedica.pl
Background: It has been demonstrated that there is a significant reduction in the incidence of
cardiovascular events, mortality rates, and worsening kidney disease in patients using …

[HTML][HTML] Effect of SGLT-2 inhibitor, dapagliflozin, on left ventricular remodeling in patients with type 2 diabetes and HFrEF

Q Fu, L Zhou, Y Fan, F Liu, Y Fan, X Zhang… - BMC Cardiovascular …, 2023 - Springer
The current study evaluated the effect of SGLT-2 inhibitor, dapagliflozin, on left ventricular
remodeling in patients with type 2 diabetes and HFrEF. 60 patients were randomized (1: 1) …

Macrod1 suppresses diabetic cardiomyopathy via regulating PARP1-NAD+-SIRT3 pathway

Y Liu, H Qiu, H Xia, Y Feng, J Deng, Y Yuan… - Acta Pharmacologica …, 2024 - nature.com
Diabetic cardiomyopathy (DCM), one of the most serious long-term consequences of
diabetes, is closely associated with oxidative stress, inflammation and apoptosis in the heart …

Cardio‐renal‐metabolic disease in primary care setting

M Ibrahim, EM Ba‐Essa, J Baker… - Diabetes/metabolism …, 2024 - Wiley Online Library
In the primary care setting providers have more tools available than ever before to impact
positively obesity, diabetes, and their complications, such as renal and cardiac diseases. It is …

[HTML][HTML] A review and meta-analysis of the safety and efficacy of using glucagon-like peptide-1 receptor agonists

EH Hu, ML Tsai, Y Lin, TS Chou, TH Chen - Medicina, 2024 - mdpi.com
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been used to reduce glucose
levels in patients with type 2 diabetes mellitus since 2005. This meta-analysis discusses the …