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The lungs were long thought to be sterile until technical advances uncovered the presence
of the lung microbial community. The microbiome of healthy lungs is mainly derived from the …

Tens of thousands of patients with advanced lung diseases may be eligible to be considered
as potential candidates for lung transplant around the world each year. The timing of referral …

CT scanning can also aid in identifying an aetiology of bronchiectasis eg Allergic
bronchopulmonary aspergillosis (ABPA), Non-tuberculous mycobacteria (NTM), primary …

Background Bronchiectasis is a common but neglected chronic lung disease. Most
epidemiological data are limited to cohorts from Europe and the USA, with few data from low …

Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to
failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms …

Rationale: Eradication and suppression of Pseudomonas aeruginosa is a key priority in
national guidelines for bronchiectasis and is a major focus of drug development and clinical …

Rationale: Exacerbations are key events in the natural history of bronchiectasis, but clinical
predictors and outcomes of patients with frequently exacerbating disease are not well …

Bronchiectasis is a clinical and radiological diagnosis associated with cough, sputum
production and recurrent respiratory infections. The clinical presentation inevitably overlaps …

Background Patients with bronchiectasis often have concurrent comorbidities, but the
nature, prevalence, and impact of these comorbidities on disease severity and outcome are …