Pathophysiology of atherosclerosis

S Jebari-Benslaiman, U Galicia-García… - International journal of …, 2022 - mdpi.com
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

miRNA deregulation in cancer cells and the tumor microenvironment

R Rupaimoole, GA Calin, G Lopez-Berestein, AK Sood - Cancer discovery, 2016 - AACR
Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

MicroRNA regulation of atherosclerosis

MW Feinberg, KJ Moore - Circulation research, 2016 - Am Heart Assoc
Atherosclerosis and its attendant clinical complications, such as myocardial infarction,
stroke, and peripheral artery disease, are the leading cause of morbidity and mortality in …

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives

W Poller, S Dimmeler, S Heymans, T Zeller… - European heart …, 2018 - academic.oup.com
Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …

The potential role of miRNAs in the pathogenesis of cardiovascular diseases–A focus on signaling pathways interplay

EG Khidr, AI Abulsoud, AA Doghish… - … -Research and Practice, 2023 - Elsevier
For the past two decades since their discovery, scientists have linked microRNAs (miRNAs)
to posttranscriptional regulation of gene expression in critical cardiac physiological and …

Longterm exercise-derived exosomal miR-342-5p: a novel exerkine for cardioprotection

Z Hou, X Qin, Y Hu, X Zhang, G Li, J Wu, J Li… - Circulation …, 2019 - Am Heart Assoc
Rationale: Exercise training, in addition to reducing cardiovascular risk factors, confers direct
protection against myocardial ischemia/reperfusion injury and has been associated with …

[HTML][HTML] Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets

DP Ramji, TS Davies - Cytokine & growth factor reviews, 2015 - Elsevier
Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

D Zhou, C Huang, Z Lin, S Zhan, L Kong, C Fang, J Li - Cellular signalling, 2014 - Elsevier
Monocytes/macrophages are heterogeneous and versatile cells that could undergo their
phenotypically/functionally dynamic switch in response to the microenvironment signals …

MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1

A Schober, M Nazari-Jahantigh, Y Wei, K Bidzhekov… - Nature medicine, 2014 - nature.com
Atherosclerosis, a hyperlipidemia-induced chronic inflammatory process of the arterial wall,
develops preferentially at sites where disturbed laminar flow compromises endothelial cell …

microRNAs in cardiovascular diseases: current knowledge and the road ahead

G Condorelli, MVG Latronico, E Cavarretta - Journal of the American …, 2014 - jacc.org
Over the last few years, the field of microribonucleic acid (miRNA) in cardiovascular biology
and disease has expanded at an incredible pace. miRNAs are themselves part of a larger …