[HTML][HTML] Two centuries of vaccination: historical and conceptual approach and future perspectives

DA Montero, RM Vidal, J Velasco, LJ Carreño… - Frontiers in public …, 2024 - frontiersin.org
Over the past two centuries, vaccines have been critical for the prevention of infectious
diseases and are considered milestones in the medical and public health history. The World …

[HTML][HTML] Potentials of saponins-based adjuvants for nasal vaccines

K Chen, N Wang, X Zhang, M Wang, Y Liu… - Frontiers in …, 2023 - frontiersin.org
Respiratory infections are a major public health concern caused by pathogens that colonize
and invade the respiratory mucosal surface. Nasal vaccines have the advantage of …

[HTML][HTML] AZD1222-induced nasal antibody responses are shaped by prior SARS-CoV-2 infection and correlate with virologic outcomes in breakthrough infection

AA Aksyuk, H Bansal, D Wilkins, AM Stanley… - Cell Reports …, 2023 - cell.com
The nasal mucosa is an important initial site of host defense against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection. However, intramuscularly administered …

[HTML][HTML] Robust humoral and cellular recall responses to AZD1222 attenuate breakthrough SARS-CoV-2 infection compared to unvaccinated

J Maaske, S Sproule, AR Falsey… - Frontiers in …, 2023 - frontiersin.org
Background Breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection in coronavirus disease 2019 (COVID-19) vaccinees typically produces milder …

[HTML][HTML] The bacterial spore as a mucosal vaccine delivery system

A Saggese, L Baccigalupi, G Donadio, E Ricca… - International Journal of …, 2023 - mdpi.com
The development of efficient mucosal vaccines is strongly dependent on the use of
appropriate vectors. Various biological systems or synthetic nanoparticles have been …

[HTML][HTML] Oral mucosa immunity: ultimate strategy to stop spreading of pandemic viruses

H Jang, M Matsuoka, M Freire - Frontiers in Immunology, 2023 - frontiersin.org
Global pandemics are most likely initiated via zoonotic transmission to humans in which
respiratory viruses infect airways with relevance to mucosal systems. Out of the known …

[HTML][HTML] Research progress in the development of natural-product-based mucosal vaccine adjuvants

Y Gao, Y Guo - Frontiers in Immunology, 2023 - frontiersin.org
Mucosal vaccines have great potential and advantages in preventing infection caused by
multiple pathogens. In developing mucosal vaccines, the biggest challenge comes from …

[HTML][HTML] Investigation into the safety, and serological responses elicited by delivery of live intranasal vaccines for bovine herpes virus type 1, bovine respiratory …

A Flynn, C McAloon, K Sugrue, R Fitzgerald… - Frontiers in Veterinary …, 2024 - frontiersin.org
Despite the fact that pneumonia remains a leading cause of mortality and morbidity in pre-
weaned calves, relatively little is known regarding the effects of the concurrent …

Vaccine Strategies to Elicit Mucosal Immunity

Y Song, F Mehl, SL Zeichner - Vaccines, 2024 - mdpi.com
Vaccines are essential tools to prevent infection and control transmission of infectious
diseases that threaten public health. Most infectious agents enter their hosts across mucosal …

The red alga Porphyridium as a host for molecular farming: Efficient production of immunologically active hepatitis C virus glycoprotein

A Hammel, LM Cucos, I Caras… - Proceedings of the …, 2024 - National Acad Sciences
Microalgae are promising production platforms for the cost-effective production of
recombinant proteins. We have recently established that the red alga Porphyridium …