Abstract Purpose of Review Pulmonary arterial hypertension (PAH) leads to progressive
increases in pulmonary vascular resistance (PVR), right heart failure, and death if left …

Vascular remodeling is a basic pathological process in various diseases characterized by
abnormal changes in the morphology, structure, and function of vascular cells, such as …

Rationale: Although many familial cases of pulmonary arterial hypertension exhibit an
autosomal dominant mode of inheritance with the majority having mutations in essential …

Background and Purpose Macrophage infiltration into the lungs is a characteristic of
pulmonary hypertension (PH). Glycolysis is the main metabolic pathway for macrophage …

Pulmonary hypertension (PH) is caused by chronic hypoxia that induces the migration and
proliferation of pulmonary arterial smooth muscle cells (PASMCs), eventually resulting in …

Pulmonary arterial hypertension (PAH) is a vascular disease that is characterized by
elevated pulmonary arterial pressure (PAP) due to progressive vascular remodeling …

Introduction Pulmonary arterial hypertension (PAH) is a life-threatening disease without
effective therapies. PAH is associated with a progressive increase in pulmonary vascular …

Pulmonary arterial hypertension (PAH) is a progressive and fatal vascular disease in which
high blood pressure in the pulmonary artery and remodeling of the pulmonary vasculature …

Pulmonary arterial remodeling is a crucial cause of increased pulmonary artery pressure
during pulmonary hypertension (PH). Recently, growing evidence has upheld the …

Pulmonary hypertension (PH) is characterized by vascular remodeling and sustained
increase in right ventricular systolic pressure. The molecular mechanisms behind PH …