[HTML][HTML] Phage delivered CRISPR-Cas system to combat multidrug-resistant pathogens in gut microbiome
The Host-microbiome interactions that exist inside the gut microbiota operate in a synergistic
and abnormal manner. Additionally, the normal homeostasis and functioning of gut …
and abnormal manner. Additionally, the normal homeostasis and functioning of gut …
Inner ear drug delivery for sensorineural hearing loss: current challenges and opportunities
SS Liu, R Yang - Frontiers in Neuroscience, 2022 - frontiersin.org
Most therapies for treating sensorineural hearing loss are challenged by the delivery across
multiple tissue barriers to the hard-to-access anatomical location of the inner ear. In this …
multiple tissue barriers to the hard-to-access anatomical location of the inner ear. In this …
Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing
CRISPR–Cas9 technology has revolutionized genome editing and is applicable to the
organoid field. However, precise integration of exogenous DNA sequences into human …
organoid field. However, precise integration of exogenous DNA sequences into human …
Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo
Adeno-associated virus (AAV) vectors are important delivery platforms for therapeutic
genome editing but are severely constrained by cargo limits. Simultaneous delivery of …
genome editing but are severely constrained by cargo limits. Simultaneous delivery of …
Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing
The mechanism underlying unwanted structural variations induced by CRISPR-Cas9
remains poorly understood, and no effective strategy is available to inhibit the generation of …
remains poorly understood, and no effective strategy is available to inhibit the generation of …
CRISPR/Cas9-based precise excision of SlHyPRP1 domain (s) to obtain salt stress-tolerant tomato
Key message CRISPR/Cas9-based multiplexed editing of SlHyPRP1 resulted in precise
deletions of its functional motif (s), thereby resulting in salt stress-tolerant events in cultivated …
deletions of its functional motif (s), thereby resulting in salt stress-tolerant events in cultivated …
Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease
Adult kidney organoids have been described as strictly tubular epithelia and termed
tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that …
tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that …
Establishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver
The liver is composed of two epithelial cell types: hepatocytes and liver ductal cells. Culture
conditions for expansion of human liver ductal cells in vitro as organoids were previously …
conditions for expansion of human liver ductal cells in vitro as organoids were previously …
The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer
L Zhang, Y Li, Q Wang, Z Chen, X Li, Z Wu, C Hu… - Molecular Cancer, 2020 - Springer
Abstract Background PI3K/AKT is a vital signaling pathway in humans. Recently, several
PI3K/AKT inhibitors were reported to have the ability to reverse cancer multidrug resistance …
PI3K/AKT inhibitors were reported to have the ability to reverse cancer multidrug resistance …
[HTML][HTML] Induction of apoptosis and ferroptosis by a tumor suppressing magnetic field through ROS-mediated DNA damage
LQ Yuan, C Wang, DF Lu, XD Zhao, LH Tan… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Magnetic field (MF) is being used in antitumor treatment; however, the underlying biological
mechanisms remain unclear. In this study, the potency and mechanism of a previously …
mechanisms remain unclear. In this study, the potency and mechanism of a previously …