An imbalance between excitation and inhibition has been a longstanding proposed
mechanism regarding ictogenesis and epileptogenesis. This imbalance is related to …

Brain function is a product of the balance between excitatory and inhibitory (E/I) brain
activity. Variation in the regulation of this activity is thought to give rise to normal variation in …

Post-mortem studies allow for the direct investigation of brain tissue in those with autism and
related disorders. Several review articles have focused on aspects of post-mortem …

Atypical behavioral responses to environmental sounds are common in autistic children and
adults, with 50–70% of this population exhibiting decreased sound tolerance (DST) at some …

Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

Abstract Zuranolone (SAGE-217) is a novel, synthetic, clinical stage neuroactive steroid
GABA A receptor positive allosteric modulator designed with the pharmacokinetic properties …

In this review, we discuss the significance of the synaptic excitation/inhibition (E/I) balance in
the context of homeostatic plasticity, whose primary goal is thought to maintain neuronal …

Sensory abnormalities are commonly recognized as diagnostic criteria in autism spectrum
disorder (ASD), as reported in the last edition of the Diagnostic and Statistical Manual of …

Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively)
are widely recognized as core components of stress granules (SGs). We report that G3BPs …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …