The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma

R Donne, A Lujambio - Hepatology, 2023 - journals.lww.com
The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …

[HTML][HTML] Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma

D Du, C Liu, M Qin, X Zhang, T Xi, S Yuan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is an aggressive human cancer with increasing incidence
worldwide. Multiple efforts have been made to explore pharmaceutical therapies to treat …

Hepatobiliary cancers, version 2.2021, NCCN clinical practice guidelines in oncology

AB Benson, MI D'Angelica, DE Abbott… - Journal of the National …, 2021 - jnccn.org
The NCCN Guidelines for Hepatobiliary Cancers focus on the screening, diagnosis, staging,
treatment, and management of hepatocellular carcinoma (HCC), gallbladder cancer, and …

[HTML][HTML] Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 edition)

J Zhou, H Sun, Z Wang, W Cong, J Wang, M Zeng… - Liver cancer, 2020 - karger.com
Background: Primary liver cancer, around 90% are hepatocellular carcinoma in China, is the
fourth most common malignancy and the second leading cause of tumor-related death …

Donafenib versus sorafenib in first-line treatment of unresectable or metastatic hepatocellular carcinoma: a randomized, open-label, parallel-controlled phase II-III trial

S Qin, F Bi, S Gu, Y Bai, Z Chen, Z Wang… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Donafenib, a novel multikinase inhibitor and a deuterated sorafenib derivative,
has shown efficacy in phase Ia and Ib hepatocellular carcinoma (HCC) studies. This study …

[HTML][HTML] 2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates and insights

DY Xie, ZG Ren, J Zhou, J Fan… - Hepatobiliary surgery and …, 2020 - ncbi.nlm.nih.gov
2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates
and insights - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Lenvatinib plus pembrolizumab versus lenvatinib plus placebo for advanced hepatocellular carcinoma (LEAP-002): a randomised, double-blind, phase 3 trial

JM Llovet, M Kudo, P Merle, T Meyer, S Qin… - The Lancet …, 2023 - thelancet.com
Background Systemic therapies have improved the management of hepatocellular
carcinoma, but there is still a need to further enhance overall survival in first-line advanced …

Camrelizumab in patients with previously treated advanced hepatocellular carcinoma: a multicentre, open-label, parallel-group, randomised, phase 2 trial

S Qin, Z Ren, Z Meng, Z Chen, X Chai, J Xiong… - The Lancet …, 2020 - thelancet.com
Background Blocking the interaction between PD-1 and its ligands is a promising treatment
strategy for advanced hepatocellular carcinoma. This study aimed to assess the antitumour …

mRECIST for HCC: performance and novel refinements

JM Llovet, R Lencioni - Journal of hepatology, 2020 - Elsevier
Summary In 2010, modified RECIST (mRECIST) criteria were proposed as a way of
adapting the RECIST criteria to the particularities of hepatocellular carcinoma (HCC). We …

Apatinib as second-line or later therapy in patients with advanced hepatocellular carcinoma (AHELP): a multicentre, double-blind, randomised, placebo-controlled …

S Qin, Q Li, S Gu, X Chen, L Lin, Z Wang… - The lancet …, 2021 - thelancet.com
Background Inhibition of vascular endothelial growth factor receptor (VEGFR) has shown
antitumour activity in advanced hepatocellular carcinoma, but few studies of VEGFR …