The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

Regenerative processes that maintain the function of the gastrointestinal (GI) epithelium are
critical for health and survival of multicellular organisms. In insects and vertebrates, intestinal …

Compartmentalization of the gastrointestinal (GI) tract of metazoans is critical for health. GI
compartments contain specific microbiota, and microbiota dysbiosis is associated with …

Deciphering contributions of specific cell types to organ function is experimentally
challenging. The Drosophila midgut is a dynamic organ with five morphologically and …

Somatic stem cells maintain tissue homeostasis by dynamically adjusting proliferation and
differentiation in response to stress and metabolic cues. Here we identify Ca2+ signalling as …

Coordination of stem cell activity with inflammatory responses is critical for regeneration and
homeostasis of barrier epithelia. The temporal sequence of cell interactions during injury …

Many adult tissues and organs are maintained by resident stem cells that are activated in
response to injury but the mechanisms that regulate stem cell activity during regeneration …

Decapentaplegic (Dpp), the fly homolog of the secreted mammalian BMP2/4 signaling
molecules, is involved in almost all aspects of fly development. Dpp has critical functions at …

Intestinal stem cells in the adult Drosophila midgut are regulated by growth factors produced
from the surrounding niche cells including enterocytes and visceral muscle. The role of the …

In adult insects, as in vertebrates, the gut epithelium is a highly regenerative tissue that can
renew itself rapidly in response to changing inputs from nutrition, the gut microbiota …