Clinical responses to checkpoint inhibitors used for cancer immunotherapy seemingly
require the presence of αβT cells that recognize tumour neoantigens, and are therefore …

T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …

INTRODUCTION T cells represent a key component of the immune system that can
recognize foreign molecules (antigens) via cognate cell surface receptors termed T cell …

Epithelial surfaces line the body and provide a crucial interface between the body and the
external environment. Tissue-resident epithelial γδ T cells represent a major T cell …

While most studies of T lymphocytes have focused on T cells reactive to complexes of
peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do …

In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells
through an 'inside out'signalling process whereby structurally diverse phosphoantigen (pAg) …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

T lymphocytes comprise cells expressing either an αβ or a γδ TCR. The riddle how αβ TCRs
are triggered by specific peptides presented in the context of MHC was elucidated some …

Vδ2+ T cells form the predominant human γδ T-cell population in peripheral blood and
mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we …

The γδ T cell lineage in humans remains much of an enigma due to the low number of
defined antigens, the non-canonical ways in which these cells respond to their environment …