Exercise is the most important physiological stimulus for increased myocardial oxygen
demand. The requirement of exercising muscle for increased blood flow necessitates an …

The spatial and temporal scales of cardiac organogenesis and pathogenesis make
engineering of artificial heart tissue a daunting challenge. The temporal scales range from …

The oxygen dependence of mitochondrial respiration was investigated using suspensions of
mitochondria and quiescent ventricular myocytes isolated from adult rat hearts. A new …

Endothelium-derived NO is considered to be primarily an important determinant of vascular
tone and platelet activity; however, the modulation of myocardial metabolism by NO may be …

Purpose This study compares the effects of stored red cells, freshly donated blood and
ultrapurified polymerized bovine haemoglobin (HBOC) on haemodynamic variables, oxygen …

The assumption that the coronary capillary blood flow is exclusively regulated by
precapillary vessels is not supported by recent data. Rather, the complex coronary capillary …

The effect of anemia on the coronary microcirculation was studied in young male rats.
Chronic anemia resulted in increased left ventricular end-diastolic pressure and decreased …

PURPOSE: To determine the feasibility of using hemoglobin (Hb) desaturation as an
indicator of myocardial oxygenation. MATERIALS AND METHODS: High-resolution gradient …

In this review the effects of carbon monoxide on tissular oxygenation, at doses which are
compatible with life, are considered. In a first section the relative CO− O 2 affinity (M*) of …

This study was performed to determine the myocyte Po 2 required to sustain normal high-
energy phosphate (HEP) levels in the in vivo heart. In 10 normal dogs, myocyte Po 2 values …