Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory
response triggered by infection, involving multifactorial and intricate molecular mechanisms …

Pyroptosis can be triggered through both canonical and non-canonical inflammasome
pathways, involving the cleavage of gasdermin (GSDM) protein family members, like …

Background Perinatal hypoxia affects a lot of neonates worldwide every year, however its
effects on the functioning of systemic circulation are not clear yet. We aimed at investigation …

Heart development relies on a topologically defined interplay between a diverse array of
cardiac cells. We finely curated spatial and single-cell measurements with subcellular …

A bstract Ethnopharmacological relevance The Danshen-Shanzha Decoction (DSD) is a
renowned herbal combination consisting of the root of Salvia miltiorrhiza Bunge (known as …

Excessive buildup of highly reactive molecules can occur due to the generation and
dysregulation of reactive oxygen species (ROS) and their associated signaling pathways …

Cardiovascular diseases (CVDs), including hypertension, atherosclerosis, myocardial
ischemia, and myocardial infarction, constitute the primary cause of mortality worldwide …

Acute respiratory distress syndrome (ARDS) is a critical illness in critically unwell patients,
characterized by refractory hypoxemia and shock. This study evaluates an early detection …

Rationale Cardiac microvascular leakage and inflammation are triggered during myocardial
infarction (MI) and contribute to heart failure. Hypoxia-inducible factor 2α (Hif2α) is highly …

高原心脏损伤(HACI) 是由于高原缺氧引起的常见组织损伤之一, 严重时可危及生命. 研究表明,
缺氧诱导因子-1α (HIF-1α) 是一种氧敏感转录因子, 在缺氧条件下显著增高 …