Background and aims Cocaine use disorder (CUD) is a significant public health issue for
which there is no Food and Drug Administration (FDA) approved medication. Drug …

Crack-cocaine dependence is a severe condition with a high mortality rate. This single case
study report details the first deep brain stimulation (DBS) trial targeting the sub-thalamic …

It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …

Cocaine use disorder (CUD) is a prevalent neuropsychiatric disorder with few existing
treatments. Thus, there is an unmet need for the identification of new pharmacological …

Psychostimulant use disorders (PSUD) affect a growing number of men and women and
exert sizable public health and economic burdens on our global society. Notably, there are …

Background Detoxification is frequently recommended as a treatment for moderate to severe
Cocaine Use Disorder (CUD). However, the response to detoxification varies among …

We have recently reported sex differences in the plasma concentrations of lysophosphatidic
acid (LPA) and alterations in LPA species in patients with alcohol and cocaine use …

Vaccination active, promising alternative immunological strategy to treat of CUD. Various
models of cocaine vaccines have been evaluated in animals and humans with relative …

Background Few studies have investigated changes in brain structure and function
associated with recovery from cocaine use disorder (CUD), and fewer still have identified …

The dopamine transporter (DAT) plays a critical role in the central nervous system and has
been implicated in numerous psychiatric disorders. The ligand-based approaches are …