The intracellular transport of organelles along an axon is crucial for the maintenance and
function of a neuron. Anterograde axonal transport has a role in supplying proteins and …

A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

Neurodegeneration is the pathological condition, in which the nervous system or neuron
loses its structure, function, or both, leading to progressive degeneration or the death of …

Microglia are the primary immune cells of the CNS, carrying out key homeostatic roles and
undergoing context-dependent and temporally regulated changes in response to injury and …

Background Astrocytes play a crucial, yet not fully elucidated role in the selective motor
neuron pathology in amyotrophic lateral sclerosis (ALS). Among other responsibilities …

Minocycline is commonly used to inhibit microglial activation. It is widely accepted that
activated microglia exert dual functions, that is, pro-inflammatory (M1) and anti-inflammatory …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a non-
cell autonomous motor neuron loss. While it is generally believed that the disease onset …

Amyotrophic lateral sclerosis (ALS) is a late-onset, fatal disorder in which the motor neurons
degenerate. The discovery of new drugs for treating ALS has been hampered by a lack of …

Objective To investigate miR‐155 in the SOD1 mouse model and human sporadic and
familial amyotrophic lateral sclerosis (ALS). Methods NanoString microRNA, microglia and …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease affecting upper and
lower motor neurons in the central nervous system. Patients with ALS develop extensive …