Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

Despite significant progress in understanding the molecular and genetic aspects of
amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the …

Amyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell
death that is thought to involve aberrant immune responses. Here we investigated the role of …

Transactive response DNA-binding protein-43 (TDP-43) is a multifunctional nucleic acid
binding protein present in ubiquitinated inclusions in tissues of patients with amyotrophic …

Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral
sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons …

At present, there are very few therapeutic options for patients affected by amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD). However, almost all patients affected by …

Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of
central nervous system (CNS) functionality. It has been shown that neuroinflammation …

Abstract Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disease in
adults. Classical ALS is characterized by the death of upper and lower motor neurons …

Microglia are the resident innate immune cells of the central nervous system that mediate
brain homeostasis maintenance. Microglia-mediated neuroinflammation is a hallmark …

Astrocytes are involved in non‐cell‐autonomous pathogenic cascades in amyotrophic
lateral sclerosis (ALS); however, their role is still debated. We show that astrocytic NF‐κB …