[HTML][HTML] Molecular biomarkers and their implications for the early diagnosis of selected neurodegenerative diseases
J Doroszkiewicz, M Groblewska, B Mroczko - International Journal of …, 2022 - mdpi.com
The degeneration and dysfunction of neurons are key features of neurodegenerative
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …
The human gut microbiota in people with amyotrophic lateral sclerosis
K Nicholson, K Bjornevik, G Abu-Ali… - … Lateral Sclerosis and …, 2021 - Taylor & Francis
Objective To characterize the gut microbiota in people with amyotrophic lateral sclerosis
(ALS) relative to controls and to test the hypothesis that butyrate-producing bacteria are less …
(ALS) relative to controls and to test the hypothesis that butyrate-producing bacteria are less …
Molecular insight in the multifunctional activities of Withaferin A
Herbal medicine which involves the use of plants for their medicinal value, dates as far back
as the origin of mankind and demonstrates an array of applications including cardiovascular …
as the origin of mankind and demonstrates an array of applications including cardiovascular …
Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease that causes motor neuron
degeneration, progressive motor dysfunction, paralysis, and death. Although multiple …
degeneration, progressive motor dysfunction, paralysis, and death. Although multiple …
[HTML][HTML] Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations
Background Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in
motor neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in …
motor neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in …
[HTML][HTML] Emerging therapies and novel targets for TDP-43 proteinopathy in ALS/FTD
Nuclear clearance and cytoplasmic mislocalization of the essential RNA binding protein,
TDP-43, is a pathologic hallmark of amyotrophic lateral sclerosis, frontotemporal dementia …
TDP-43, is a pathologic hallmark of amyotrophic lateral sclerosis, frontotemporal dementia …
Whole-genome sequencing reveals that variants in the interleukin 18 receptor accessory protein 3′ UTR protect against ALS
The noncoding genome is substantially larger than the protein-coding genome but has been
largely unexplored by genetic association studies. Here, we performed region-based rare …
largely unexplored by genetic association studies. Here, we performed region-based rare …
[HTML][HTML] The peripheral immune system and amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that is defined by
loss of upper and lower motor neurons, associated with accumulation of protein aggregates …
loss of upper and lower motor neurons, associated with accumulation of protein aggregates …
Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …
[HTML][HTML] Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia
L Renaud, V Picher-Martel, P Codron… - Acta neuropathologica …, 2019 - Springer
Abstract Ubiquilin-2 (UBQLN2) is a member of the ubiquilin family, actively implicated in the
degradation of misfolded and redundant proteins through the ubiquitin-proteasome system …
degradation of misfolded and redundant proteins through the ubiquitin-proteasome system …