TDP-43/FUS in motor neuron disease: Complexity and challenges
Amyotrophic lateral sclerosis (ALS), a common motor neuron disease affecting two per
100,000 people worldwide, encompasses at least five distinct pathological subtypes …
100,000 people worldwide, encompasses at least five distinct pathological subtypes …
[HTML][HTML] TDP-43 and inflammation: implications for amyotrophic lateral sclerosis and frontotemporal dementia
The abnormal mislocalisation and ubiquitinated protein aggregation of the TAR DNA
binding protein 43 (TDP-43) within the cytoplasm of neurons and glia in the central nervous …
binding protein 43 (TDP-43) within the cytoplasm of neurons and glia in the central nervous …
[HTML][HTML] Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation
C Parisi, I Arisi, N D'Ambrosi, AE Storti, R Brandi… - Cell death & …, 2013 - nature.com
MicroRNAs (miRNAs) regulate gene expression at post-transcriptional level and are key
modulators of immune system, whose dysfunction contributes to the progression of …
modulators of immune system, whose dysfunction contributes to the progression of …
Connecting TDP-43 pathology with neuropathy
JR Klim, G Pintacuda, LA Nash, IG San Juan… - Trends in …, 2021 - cell.com
Transactive response DNA-binding protein 43 kDa (TDP-43), a multifunctional nucleic acid-
binding protein, is a primary component of insoluble aggregates associated with several …
binding protein, is a primary component of insoluble aggregates associated with several …
SQSTM1 mutations–bridging Paget disease of bone and ALS/FTLD
SL Rea, V Majcher, MS Searle, R Layfield - Experimental cell research, 2014 - Elsevier
Paget disease of bone (PDB) is a skeletal disorder common in Western Europe but
extremely rare in the Indian subcontinent and Far East. The condition has a strong genetic …
extremely rare in the Indian subcontinent and Far East. The condition has a strong genetic …
[HTML][HTML] NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma
BC McFarland, SW Hong, R Rajbhandari, GB Twitty Jr… - PloS one, 2013 - journals.plos.org
Glioblastoma (GBM) is the most aggressive, neurologically destructive and deadly tumor of
the central nervous system (CNS). In GBM, the transcription factors NF-κB and STAT3 are …
the central nervous system (CNS). In GBM, the transcription factors NF-κB and STAT3 are …
Astrocytes expressing ALS‐linked mutant FUS induce motor neuron death through release of tumor necrosis factor‐alpha
Mutations in fused in sarcoma (FUS) are linked to amyotrophic lateral sclerosis (ALS), a fatal
neurodegenerative disease affecting both upper and lower motor neurons. While it is …
neurodegenerative disease affecting both upper and lower motor neurons. While it is …
[HTML][HTML] MicroRNA-125b regulates microglia activation and motor neuron death in ALS
C Parisi, G Napoli, S Amadio, A Spalloni… - Cell Death & …, 2016 - nature.com
Understanding the means by which microglia self-regulate the neuroinflammatory response
helps modulating their reaction during neurodegeneration. In amyotrophic lateral sclerosis …
helps modulating their reaction during neurodegeneration. In amyotrophic lateral sclerosis …
[HTML][HTML] The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two progressive,
fatal neurodegenerative syndromes with considerable clinical, genetic and pathological …
fatal neurodegenerative syndromes with considerable clinical, genetic and pathological …
Amyotrophic lateral sclerosis: Current perspectives from basic research to the clinic
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive degeneration of upper and lower motoneurons, leading to muscle weakness …
progressive degeneration of upper and lower motoneurons, leading to muscle weakness …