Increasing evidence suggests that the pathogenesis of neurodegenerative diseases
including amyotrophic lateral sclerosis (ALS) is not restricted to the neurons but attributed to …

Expansion of a hexanucleotide repeat (HRE), GGGGCC, in the C9ORF72 gene is
recognized as the most common cause of familial amyotrophic lateral sclerosis (FALS) …

Transactivating response region DNA binding protein 43 (TDP-43) pathology is prevalent in
dementia, but the cell type–specific effects of TDP-43 pathology are not clear, and …

In recent years there has been an increasing awareness of the role of P2X7, a receptor for
extracellular ATP, in modulating physiopathological mechanisms in the central nervous …

TAR DNA-binding protein 43 (TDP-43) is a major component in aggregates of ubiquitinated
proteins in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration …

Proteinopathy and neuroinflammation are two main hallmarks of neurodegenerative
diseases. They also represent rare common events in an exceptionally broad landscape of …

Background Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa
(TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases …

The C9orf72 repeat expansion is the most common genetic cause of amyotrophic lateral
sclerosis (ALS) and/or frontotemporal dementia (FTD). Non‐canonical translation of the …

Ras‐GTPase‐activating protein (GAP)‐binding protein 1 (G3BP1) is a multi‐functional
protein that is best known for its role in the assembly and dynamics of stress granules …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder. In motor neurons of
ALS, TAR DNA binding protein-43 (TDP-43), a nuclear protein encoded by TARDBP, is …