While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and
frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal …

Chronic inflammatory diseases are considered to be one of the biggest threats to human
health. Most prescribed pharmaceutical drugs aiming to treat these diseases are …

The cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of
degenerating neurons in amyotrophic lateral sclerosis (ALS) and subsets of frontotemporal …

Neurodegenerative diseases share common features, including catastrophic neuronal loss
that leads to cognitive or motor dysfunction. Neuronal injury occurs in an inflammatory milieu …

TDP-43 is a DNA/RNA-binding protein associated with different neurodegenerative
diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration …

Amyotrophic Lateral Sclerosis (ALS), neurodegenerative motor neuron disorder is
characterized as multisystem disease with important contribution of genetic factors. The …

Neuroinflammation is a striking hallmark of amyotrophic lateral sclerosis (ALS) and other
neurodegenerative disorders. Previous studies have shown the contribution of glial cells …

The majority of amyotrophic lateral sclerosis (ALS) cases as well as many patients suffering
from frontotemporal lobar dementia (FTLD) with ubiquitinated inclusion bodies show TDP-43 …

To investigate the role of neuronal NF-κB activity in pathogenesis of amyotrophic lateral
sclerosis (ALS), we generated transgenic mice with neuron-specific expression of a super …

Fatty acid binding proteins (FABPs) are key regulators of lipid metabolism, energy
homeostasis, and inflammation. They participate in fatty acid metabolism by regulating their …