Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …

Background Neuronal cytoplasmic inclusions containing TAR DNA-binding protein 43 (TDP-
43) are a neuropathological feature of several neurodegenerative diseases, including …

The pathogenesis of Parkinson's disease (PD) remains unclear, and there is no disease-
modifying agent for PD. Withaferin A (WA), a naturally occurring compound, has emerged as …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating heterogeneous disease with
still no convincing therapy. To identify the most strategically significant hallmarks for …

Amyotrophic lateral sclerosis (ALS) is an adult-onset paralytic disease characterized by
progressive degeneration of upper and lower motor neurons in the motor cortex, brainstem …

Since its discovery in 2006, TAR DNA binding protein 43 (TDP‐43) has driven rapidly
evolving research in neurodegenerative diseases including amyotrophic lateral sclerosis …

Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is a pathological signature of
amyotrophic lateral sclerosis (ALS). Although accumulating evidence suggests the …

The presence of foreign or misplaced nucleic acids is a dangerous signal that triggers innate
immune responses by activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a
massive neuroinflammatory reaction, which plays a key role in the progression of the …

Failure to clear damaged mitochondria via mitophagy disrupts physiological function and
may initiate damage signaling via inflammatory cascades, although how these pathways …