RIPK1 is a master regulator of multiple cell death pathways, including apoptosis and
necroptosis, and inflammation. Importantly, activation of RIPK1 has also been shown to …

Amyotrophic lateral sclerosis (ALS) and Frontotemporal Degeneration (FTD) are
neurodegenerative disorders, related by deterioration of motor and cognitive functions and …

Mutations in more than 10 genes are reported to cause familial amyotrophic lateral sclerosis
(ALS). Among these genes, optineurin (OPTN) is virtually the only gene that is considered to …

Neurodegenerative diseases are a heterogeneous group of disorders whose incidence is
likely to duplicate in the next 30 years along with the progressive aging of the western …

In amyotrophic lateral sclerosis (ALS), upregulation in expression and activity of the ABC
transporter P-glycoprotein (P-gp) driven by disease advancement progressively reduces …

Evidence from patients with sporadic and familiar amyotrophic lateral sclerosis (ALS) and
from models based on the overexpression of mutant SOD1 found in a small subset of …

Despite indisputable progress in the molecular and genetic aspects of amyotrophic lateral
sclerosis (ALS), a mechanistic comprehension of the neurodegenerative processes typical …

Dyslipidemia is considered an essential component of the pathological process of
amyotrophic lateral sclerosis (ALS), a fatal motor neuron disease. Although TAR DNA …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by
progressive and selective loss of motor neurons. The discovery of mutations in the gene …

Since its initial involvement in numerous neurodegenerative pathologies in 2006, either as a
principal actor or as a cofactor, new pathologies implicating transactive response (TAR) …