Background TDP-43 has been identified as a disease-associated protein in several chronic
neurodegenerative disorders and increasing evidence suggests its potentially pathogenic …

Impairment of proteostasis network is one of the characteristic features of many age-related
neurodegenerative disorders including autosomal dominantly inherited Huntington's …

Withania somnifera (WS; commonly known as Ashwagandha or Indian ginseng) is a
medicinal plant whose extracts have been in use for centuries in various regions of the world …

Background Mutations in the small RNA-binding protein TDP-43 lead to the formation of
insoluble cytoplasmic aggregates that have been associated with the onset and progression …

Approximately 20% of cases of familial amyotrophic lateral sclerosis (ALS) are caused by
mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). Recent studies have …

The NF-κB (nuclear factor K-light-chain-enhancer of activated B cells) transcription factor
family is critical for modulating the immune proinflammatory response throughout the body …

Modestly increased expression of transactive response DNA binding protein (TDP-43) gene
have been reported in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that has a complex
genetic basis. Through advancements in genetic screening, researchers have identified …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
upper and lower motoneuron death. Mutations in the gene for superoxide dismutase 1 …

Abnormal distribution, modification and aggregation of transactivation response DNA‐
binding protein 43 (TDP‐43) are the hallmarks of multiple neurodegenerative diseases …