Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases

T Hu, Q Wu, Q Yao, K Jiang, J Yu, Q Tang - Ageing research reviews, 2022 - Elsevier
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, and fatty acid
metabolism has been well studied. Short-chain fatty acids (SCFAs) have been less …

Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications

H Zhang, K Yang, F Chen, Q Liu, J Ni, W Cao… - Frontiers in …, 2022 - frontiersin.org
The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received
special attention because of its function in the development and progression of …

Fibrin clot properties in cardiovascular disease: from basic mechanisms to clinical practice

M Ząbczyk, RAS Ariëns, A Undas - Cardiovascular research, 2023 - academic.oup.com
Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

The role of aldehyde dehydrogenase 2 in cardiovascular disease

J Zhang, Y Guo, X Zhao, J Pang, C Pan… - Nature Reviews …, 2023 - nature.com
Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …

Obesity phenotypes and cardiovascular risk: from pathophysiology to clinical management

A Preda, F Carbone, A Tirandi, F Montecucco… - Reviews in Endocrine …, 2023 - Springer
Obesity epidemic reached the dimensions of a real global health crisis with more than one
billion people worldwide living with obesity. Multiple obesity-related mechanisms cause …

Dietary inflammatory potential and biological aging among US adults: a population-based study

R Xie, Z Ning, M Xiao, L Li, M Liu, Y Zhang - Aging clinical and …, 2023 - Springer
Objectives The rate of biological aging is influenced by various factors such as genetics,
environment, and diet. The dietary inflammatory index (DII) is strongly associated with …

[HTML][HTML] SIRT1 and SIRT6: The role in aging-related diseases

Y You, W Liang - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2023 - Elsevier
Aging is characterized by progressive functional deterioration with increased risk of
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …

Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice

Y Zhang, X Wang, XK Li, SJ Lv, HP Wang… - European Heart …, 2023 - academic.oup.com
Aims The mechanisms underlying ageing-induced vascular remodelling remain unclear.
This study investigates the role and underlying mechanisms of the cytoplasmic deacetylase …

Circadian regulation in aging: Implications for spaceflight and life on earth

D Malhan, B Schoenrock, M Yalçin, D Blottner… - Aging …, 2023 - Wiley Online Library
Alterations in the circadian system are characteristic of aging on Earth. With the decline in
physiological processes due to aging, several health concerns including vision loss …

Role of inflammation in cardiac remodeling after acute myocardial infarction

FA Fonseca, MC Izar - Frontiers in physiology, 2022 - frontiersin.org
Atherosclerosis is defined as an inflammatory disease. Low-grade inflammation is present in
all phases of the cardiovascular continuum, since the establishment of cardiovascular risk …