The cGAS–STING pathway is an evolutionarily conserved immune signaling pathway critical
for microbial defense. Unlike other innate immune pathways that largely rely on stationary …

Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative
diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger …

Long‐term neurological deficits after severe traumatic brain injury (TBI), including cognitive
dysfunction and emotional impairments, can significantly impair rehabilitation. Glial …

Brain inflammation is regarded as one of the leading causes that aggravates secondary
brain injury and hinders the prognosis of ischemic stroke. After ischemic stroke, high …

Background Activated microglia play a key role in initiating the inflammatory cascade
following ischemic stroke and exert proinflammatory or anti-inflammatory effects, depending …

The cyclic guanosine monophosphate–adenosine monophosphate (GMP‐AMP) synthase‐
Stimulator of Interferon Genes (cGAS‐STING) pathway is a critical innate immune …

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is
a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous …

Pain is a common clinical condition. However, the mechanisms underlying pain are not yet
fully understood. It is known that the neuroimmune system plays a critical role in the …

Abstract The Stimulator of Interferon Genes (STING) is predominantly expressed in immune
cells, including macrophages, natural killer cells, dendritic cells, and T cells, functioning as a …

The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell
death. Cell free-double strand DNA (dsDNA) segments from ischemic tissue debris are …