Structures, functions, and mechanisms of filament forming enzymes: a renaissance of enzyme filamentation

CK Park, NC Horton - Biophysical reviews, 2019 - Springer
Filament formation by non-cytoskeletal enzymes has been known for decades, yet only
relatively recently has its wide-spread role in enzyme regulation and biology come to be …

[HTML][HTML] The return of malonyl-CoA to the brain: Cognition and other stories

R Fadó, R Rodríguez-Rodríguez, N Casals - Progress in lipid research, 2021 - Elsevier
Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly
regulate the intracellular levels of the metabolic intermediary malonyl-CoA, which is a …

Functionalized carbon nanotube and graphene oxide embedded electrically conductive hydrogel synergistically stimulates nerve cell differentiation

X Liu, AL Miller, S Park, BE Waletzki… - … applied materials & …, 2017 - ACS Publications
Nerve regeneration after injury is a critical medical issue. In previous work, we have
developed an oligo (poly (ethylene glycol) fumarate)(OPF) hydrogel incorporated with …

Effective nerve cell modulation by electrical stimulation of carbon nanotube embedded conductive polymeric scaffolds

Z Zhou, X Liu, W Wu, S Park, AL Miller II, A Terzic… - Biomaterials …, 2018 - pubs.rsc.org
Biomimetic biomaterials require good biocompatibility and bioactivity to serve as appropriate
scaffolds for tissue engineering applications. Recent developments demonstrated that the …

NDRG1 regulates neutral lipid metabolism in breast cancer cells

CJ Sevinsky, F Khan, L Kokabee, A Darehshouri… - Breast Cancer …, 2018 - Springer
Background Altered lipid metabolism is an emerging hallmark of aggressive breast cancers.
The N-myc downstream regulated gene (NDRG1) gene plays a critical role in peripheral …

Enhanced nerve cell proliferation and differentiation on electrically conductive scaffolds embedded with graphene and carbon nanotubes

Y Sun, X Liu, MN George, S Park… - … Research Part A, 2021 - Wiley Online Library
Conduits that promote nerve regeneration are currently of great medical concern,
particularly when gaps exist between nerve endings. To address this issue, our laboratory …

Covalent crosslinking of graphene oxide and carbon nanotube into hydrogels enhances nerve cell responses

X Liu, AL Miller II, S Park, BE Waletzki… - Journal of Materials …, 2016 - pubs.rsc.org
Healing of nerve injuries is a critical medical issue. Biodegradable polymeric conduits are a
promising therapeutic solution to provide guidance for axon growth in a given space, thus …

Drosophila STING protein has a role in lipid metabolism

K Akhmetova, M Balasov, I Chesnokov - Elife, 2021 - elifesciences.org
Stimulator of interferon genes (STING) plays an important role in innate immunity by
controlling type I interferon response against invaded pathogens. In this work, we describe a …

Milk fat components with potential anticancer activity—a review

LM Rodríguez-Alcalá, MP Castro-Gomez… - Bioscience …, 2017 - portlandpress.com
During many years, the milk fat has been unfairly undervalued due to its association with
higher levels of cardiovascular diseases, dyslipidaemia or obesity, among others. However …

Discovery, structure, and function of filamentous 3-methylcrotonyl-CoA carboxylase

JJ Hu, JKJ Lee, YT Liu, C Yu, L Huang, I Aphasizheva… - Structure, 2023 - cell.com
methylcrotonyl-CoA carboxylase (MCC) is a biotin-dependent mitochondrial enzyme
necessary for leucine catabolism in most organisms. While the crystal structure of …