RNA G-quadruplexes (rG4s): genomics and biological functions
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …
have been first observed decades ago. Over the years, these four-stranded structural motifs …
[HTML][HTML] G-quadruplexes and their ligands: Biophysical methods to unravel G-quadruplex/ligand interactions
Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …
approaches that assess the binding mode and nature of the interactions between G4 …
Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back
P Kharel, G Becker, V Tsvetkov… - Nucleic acids research, 2020 - academic.oup.com
Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …
[HTML][HTML] Stress promotes RNA G-quadruplex folding in human cells
P Kharel, M Fay, EV Manasova, PJ Anderson… - Nature …, 2023 - nature.com
Guanine (G)-rich nucleic acids can fold into G-quadruplex (G4) structures under permissive
conditions. Although many RNAs contain sequences that fold into RNA G4s (rG4s) in vitro …
conditions. Although many RNAs contain sequences that fold into RNA G4s (rG4s) in vitro …
Rock, scissors, paper: How RNA structure informs function
RNA can fold back on itself to adopt a wide range of structures. These range from relatively
simple hairpins to intricate 3D folds and can be accompanied by regulatory interactions with …
simple hairpins to intricate 3D folds and can be accompanied by regulatory interactions with …
GrainGenes: a data-rich repository for small grains genetics and genomics
E Yao, VC Blake, L Cooper, CP Wight, S Michel… - Database, 2022 - academic.oup.com
As one of the US Department of Agriculture—Agricultural Research Service flagship
databases, GrainGenes (https://wheat. pw. usda. gov) serves the data and community needs …
databases, GrainGenes (https://wheat. pw. usda. gov) serves the data and community needs …
The plant noncoding transcriptome: a versatile environmental sensor
Plant noncoding RNA transcripts have gained increasing attention in recent years due to
growing evidence that they can regulate developmental plasticity. In this review article, we …
growing evidence that they can regulate developmental plasticity. In this review article, we …
G-quadruplexes in neurobiology and virology: functional roles and potential therapeutic approaches
A G-quadruplex (G4) is a four-stranded nucleic acid secondary structure maintained by
Hoogsteen hydrogen bonds established between four guanines. Experimental studies and …
Hoogsteen hydrogen bonds established between four guanines. Experimental studies and …
Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues
E Cadoni, L De Paepe, A Manicardi… - Nucleic Acids …, 2021 - academic.oup.com
Abstract G-Quadruplexes (G4s) are widely studied secondary DNA/RNA structures, naturally
occurring when G-rich sequences are present. The strategic localization of G4s in genome …
occurring when G-rich sequences are present. The strategic localization of G4s in genome …
rG4detector, a novel RNA G-quadruplex predictor, uncovers their impact on stress granule formation
M Turner, YM Danino, M Barshai… - Nucleic acids …, 2022 - academic.oup.com
RNA G-quadruplexes (rG4s) are RNA secondary structures, which are formed by guanine-
rich sequences and have important cellular functions. Existing computational tools for rG4 …
rich sequences and have important cellular functions. Existing computational tools for rG4 …