Over the last decade, mouse models have become a popular instrument for studying cardiac
arrhythmias. This review assesses in which respects a mouse heart is a miniature human …

Atrial fibrillation (AF) is the most common supraventricular arrhythmia that, for unknown
reasons, is linked to intense endurance exercise. Our studies reveal that 6 weeks of …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is
increasing with the ageing of the population. Presently available treatment options are far …

Regulation of intracellular calcium (Ca 2+) is critical in all cell types. The ryanodine receptor
(RyR), an intracellular Ca 2+ release channel located on the sarco/endoplasmic reticulum …

Cardiac ryanodine receptor type 2 plays a key role in excitation–contraction coupling. The
ryanodine receptor type 2 channel protein is modulated by various post-translational …

Objectives: This study sought to study the role of junctophilin-2 (JPH2) in atrial fibrillation
(AF). Background: JPH2 is believed to have an important role in sarcoplasmic reticulum (SR) …

Background—The progression of atrial fibrillation (AF) from paroxysmal to persistent forms
remains a major clinical challenge. Abnormal sarcoplasmic reticulum (SR) Ca2+ leak via the …

Background: Epidemiological studies have established obesity as an independent risk factor
for atrial fibrillation (AF), but the underlying pathophysiological mechanisms remain unclear …

Rationale: Atrial fibrillation (AF) is the most common cardiac arrhythmia, however the
mechanism (s) causing AF remain poorly understood and therapy is suboptimal. The …

Atrial fibrillation is the most common type of cardiac arrhythmia, and is responsible for
substantial morbidity and mortality in the general population. Current treatments have …