Background: Atrial fibrillation (AF), the most common arrhythmia, is associated with the
downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the …

Diabetes mellitus (DM) and atrial fibrillation (AF) are major unsolved public health problems,
and diabetes is an independent risk factor for AF. However, the mechanism (s) underlying …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a
major cause of death worldwide. Disturbed Na and Ca handling is known to be a major …

Abstract Ryanodine Receptors (RyRs) are massive channels that release Ca2+ from the
endoplasmic and sarcoplasmic reticulum. Hundreds of mutations are linked to malignant …

Calcium/calmodulin-dependent protein kinase II (CaMKII) has emerged as key enzyme in
many cardiac pathologies, especially heart failure (HF), myocardial infarction and …

The molecular mechanisms underlying atrial fibrillation, the most common sustained cardiac
arrhythmia, remain poorly understood. Genome-wide association studies uncovered a major …

Rationale: Autosomal-dominant mutations in ryanodine receptor type 2 (RYR2) are
responsible for≈ 60% of all catecholaminergic polymorphic ventricular tachycardia …

Despite considerable basic research into the mechanisms of atrial fibrillation (AF), not much
progress has been made in the prognosis of patients with AF. With the exception of …

Angiotensin II (Ang II) and inflammation are associated with pathogenesis of atrial fibrillation
(AF), but the underlying molecular mechanisms of these events remain unknown. The …