Atrial fibrillation (AF) is the most frequently encountered clinical arrhythmia and is associated
with increased morbidity and mortality. Ectopic activity and reentry are considered major …

Human induced pluripotent stem cell (hiPSC)-derived atrial cardiomyocytes (CMs) hold
great promise for elucidating underlying cellular mechanisms that cause atrial fibrillation …

Atrial fibrillation (AF) occurs in up to 11% of cancer patients treated with ibrutinib. The
pathophysiology of ibrutinib promoted AF is complicated, as there are multiple interactions …

Understanding the mechanism of re-entrant arrhythmias in the past 30 years has allowed
the development of almost curative therapies for many rhythm disturbances. The complex …

Introduction Abnormal calcium signaling between organelles such as the sarcoplasmic
reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases. Calcium …

Ca2+ signaling in pulmonary arterial smooth muscle cells (PASMCs) plays an important role
in pulmonary hypertension (PH). However, the underlying specific ion channel mechanisms …

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a novel class of glucose-lowering
agents that significantly improve the prognosis of patients with type 2 diabetes (T2D) and …

Abnormalities in intracellular Ca 2+ signaling have been proposed to play an essential role
in the pathophysiology of atrial arrhythmias. However, a direct observation of intracellular Ca …

Aims Gp91-containing NADPH oxidases (NOX2) are a significant source of myocardial
superoxide production. An increase in NOX2 activity accompanies atrial fibrillation (AF) …

Abstract Aims Altered Ca2+ handling in atrial fibrillation (AF) has been associated with
dysregulated protein phosphatase 1 (PP1) and subcellular heterogeneities in protein …